Ag-Catalyzed cross-dehydrogenative-coupling for the synthesis of 1,4-dioxan-2-yl substituted quinazoline hybrids in an aqueous medium

被引：0

作者：

Liu, Xixian ^{[1
]}

Xie, Dayu ^{[1
]}

Yang, Qin ^{[1
]}

Song, Zhibin ^{[1
]}

Fu, Yang ^{[1
]}

Peng, Yiyuan ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Mat, Nanchang 330022, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 37期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; DIRECT ALPHA-ARYLATION; ETHERS; HETEROARENES; CHEMISTRY; ALPHA-C(SP(3))-H; 1H-INDAZOLES; QUINOLINE; ALCOHOLS;

D O I：

10.1039/d4ob01188k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein developed an effective approach for the construction of 2- or 4-(1,4-dioxan-2-yl) substituted quinazolines under mild conditions. A silver-K2S2O8 catalyzed direct CDC reaction between quinazolines and 1,4-dioxane for the synthesis of a series of 2- or 4-(1,4-dioxan-2-yl) substituted quinazoline hybrids is reported. The reaction proceeded well in water under mild conditions and showed a broad substrate scope and good functional group compatibility. An effective silver-K2S2O8 catalyzed CDC reaction between quinazolines and 1,4-dioxane for the construction of 2- or 4-(1,4-dioxan-2-yl) substituted quinazoline hybrids is described. The reaction proceeded well in water under mild conditions.

引用

页码：7725 / 7735

页数：11

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