Role of miRNAs in macrophage-mediated kidney injury

被引：0

作者：

Li, Junxin ^{[1
,2
,3
,4
]}

Yan, Xida ^{[1
,5
]}

Wu, Zhigui ^{[1
,2
,3
,4
]}

Shen, Jing ^{[2
,3
,4
]}

Li, Yalin ^{[1
]}

Zhao, Yueshui ^{[2
,3
,4
]}

Du, Fukuan ^{[2
,3
,4
]}

Li, Mingxing ^{[2
,3
,4
]}

Wu, Xu ^{[2
,3
,4
]}

Chen, Yu ^{[2
,3
,4
]}

Xiao, Zhangang ^{[2
,3
,4
]}

Wang, Shurong ^{[1
]}

机构：

[1] Southwest Med Univ, Affiliated Hosp, Dept Pharm, Luzhou 646000, Peoples R China

[2] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou 646000, Peoples R China

[3] South Sichuan Inst Translat Med, Luzhou 646000, Peoples R China

[4] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Personalised Cell Therapy & Cell Med, Luzhou 646000, Peoples R China

[5] Mianyang Cent Hosp, Dept Pharm, Mianyang, Peoples R China

来源：

PEDIATRIC NEPHROLOGY | 2024年

关键词：

MicroRNA; Macrophage; Fibrosis; Inflammation; Kidney injury; ISCHEMIA-REPERFUSION INJURY; RENAL FIBROSIS; ALTERNATIVE ACTIVATION; TGF-BETA; IN-VIVO; INFLAMMATION; CELLS; POLARIZATION; CONTRIBUTES; PROGRESSION;

D O I：

10.1007/s00467-024-06414-5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Macrophages, crucial components of the human immune system, can be polarized into M1/M2 phenotypes, each with distinct functions and roles. Macrophage polarization has been reported to be significantly involved in the inflammation and fibrosis observed in kidney injury. MicroRNA (miRNA), a type of short RNA lacking protein-coding function, can inhibit specific mRNA by partially binding to its target mRNA. The intricate association between miRNAs and macrophages has been attracting increasing interest in recent years. This review discusses the role of miRNAs in regulating macrophage-mediated kidney injury. It shows how miRNAs can influence macrophage polarization, thereby altering the biological function of macrophages in the kidney. Furthermore, this review highlights the significance of miRNAs derived from exosomes and extracellular vesicles as a crucial mediator in the crosstalk between macrophages and kidney cells. The potential of miRNAs as treatment applications and biomarkers for macrophage-mediated kidney injury is also discussed.Graphical AbstractA higher resolution version of the Graphical abstract is available as Supplementary information

引用

下载

页码：3397 / 3410

页数：14

共 50 条

[31] 15-deoxyspergualin protects the islet graft from macrophage-mediated injury
Juang, JH
Hsu, BRS
Kuo, CH
TRANSPLANTATION PROCEEDINGS, 2002, 34 (05) : 1458 - 1459
[32] Macrophage-mediated inflammation in metabolic disease
Chawla, Ajay
Nguyen, Khoa D.
Goh, Y. P. Sharon
NATURE REVIEWS IMMUNOLOGY, 2011, 11 (11) : 738 - 749
[33] Macrophage-mediated cholesterol handling in atherosclerosis
Chistiakov, Dimitry A.
Bobryshev, Yuri V.
Orekhov, Alexander N.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2016, 20 (01) : 17 - 28
[34] ACUTE-PHASE LUNG ISCHEMIA-REFERFUSION INJURY IS MACROPHAGE-MEDIATED
EPPINGER, MJ
JONES, ML
DEEB, GM
BOLLING, SF
WARD, PA
FASEB JOURNAL, 1995, 9 (04): : A961 - A961
[35] STUDIES ON MECHANISM OF MACROPHAGE-MEDIATED CYTOTOXICITY
ZIEGLER, FG
LOHMANNMATTHES, ML
FISCHER, H
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1975, 48 (02): : 182 - 191
[36] IS CANCER A MACROPHAGE-MEDIATED AUTOAGGRESSIVE DISEASE
MUNZAROVA, M
KOVARIK, J
LANCET, 1987, 1 (8539): : 952 - 954
[37] Nonresolving macrophage-mediated inflammation in malignancy
Murray, Peter J.
FEBS JOURNAL, 2018, 285 (04) : 641 - 653
[38] MACROPHAGE-MEDIATED TUMOR CYTO-TOXICITY - ROLE OF MACROPHAGE SURFACE SIALIC-ACID
CAMERON, DJ
JOURNAL OF SURGICAL ONCOLOGY, 1983, 22 (02) : 77 - 80
[39] SELECTIVE MECHANISM OF MACROPHAGE-MEDIATED CYTOTOXICITY
HEMSWORTH, GR
WOLFF, JS
KRASKA, AR
JENSEN, KE
KENNEY, JW
MISIUNAS, V
JOURNAL OF THE RETICULOENDOTHELIAL SOCIETY, 1978, 24 (DEC): : A47 - A47
[40] Macrophage-mediated renal cell death
Kipari, T
Hughes, J
KIDNEY INTERNATIONAL, 2002, 61 (02) : 760 - 761

← 1 2 3 4 5 →