Role of miRNAs in macrophage-mediated kidney injury

被引：0
|
作者：
Li, Junxin [1 ,2 ,3 ,4 ]
Yan, Xida [1 ,5 ]
Wu, Zhigui [1 ,2 ,3 ,4 ]
Shen, Jing [2 ,3 ,4 ]
Li, Yalin [1 ]
Zhao, Yueshui [2 ,3 ,4 ]
Du, Fukuan [2 ,3 ,4 ]
Li, Mingxing [2 ,3 ,4 ]
Wu, Xu [2 ,3 ,4 ]
Chen, Yu [2 ,3 ,4 ]
Xiao, Zhangang [2 ,3 ,4 ]
Wang, Shurong [1 ]
机构：
[1] Southwest Med Univ, Affiliated Hosp, Dept Pharm, Luzhou 646000, Peoples R China
[2] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou 646000, Peoples R China
[3] South Sichuan Inst Translat Med, Luzhou 646000, Peoples R China
[4] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Personalised Cell Therapy & Cell Med, Luzhou 646000, Peoples R China
[5] Mianyang Cent Hosp, Dept Pharm, Mianyang, Peoples R China
来源：
PEDIATRIC NEPHROLOGY | 2024年
关键词：
MicroRNA; Macrophage; Fibrosis; Inflammation; Kidney injury; ISCHEMIA-REPERFUSION INJURY; RENAL FIBROSIS; ALTERNATIVE ACTIVATION; TGF-BETA; IN-VIVO; INFLAMMATION; CELLS; POLARIZATION; CONTRIBUTES; PROGRESSION;
D O I：
10.1007/s00467-024-06414-5
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Macrophages, crucial components of the human immune system, can be polarized into M1/M2 phenotypes, each with distinct functions and roles. Macrophage polarization has been reported to be significantly involved in the inflammation and fibrosis observed in kidney injury. MicroRNA (miRNA), a type of short RNA lacking protein-coding function, can inhibit specific mRNA by partially binding to its target mRNA. The intricate association between miRNAs and macrophages has been attracting increasing interest in recent years. This review discusses the role of miRNAs in regulating macrophage-mediated kidney injury. It shows how miRNAs can influence macrophage polarization, thereby altering the biological function of macrophages in the kidney. Furthermore, this review highlights the significance of miRNAs derived from exosomes and extracellular vesicles as a crucial mediator in the crosstalk between macrophages and kidney cells. The potential of miRNAs as treatment applications and biomarkers for macrophage-mediated kidney injury is also discussed.Graphical AbstractA higher resolution version of the Graphical abstract is available as Supplementary information
引用
下载
收藏
页码：3397 / 3410
页数：14
相关论文
共 50 条
  • [21] Macrophage-mediated renal injury is dependent on signaling via the JNK pathway
    Ikezumi, Y
    Hurst, L
    Atkins, RC
    Nikolic-Paterson, DJ
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (07): : 1775 - 1784
  • [22] Macrophage-mediated mechanisms of lung injury in the sensitization reaction to Echinococcus granulosus
    Li, Yu-qian
    Wang, Chun-sheng
    Zhou, Jing-ru
    Wang, Jia-ling
    Tailaiti, Subi
    Lin, Jia-ying
    Bayina, Batesurong
    Cao, Li-wei
    Ye, Jian-rong
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [23] A novel role for Hedgehog signaling in macrophage-mediated immune evasion
    Hanna, Ann
    Chen, Dongquan
    Chandrashekar, Darshan S.
    Varambally, Sooryanarayana
    Samant, Rajeev S.
    Shevde, Lalita A.
    CANCER RESEARCH, 2018, 78 (13)
  • [24] THE ROLE OF CYTOPHILIC ANTIBODY IN MACROPHAGE-MEDIATED CYTOLYSIS OF MELANOMA TARGETS
    ERICKSON, KL
    MCNEILL, CJ
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1983, 24 (MAR): : 214 - 214
  • [25] Macrophage-Mediated Inflammatory Disorders
    Jou, I-Ming
    Lin, Chiou-Feng
    Tsai, Kuen-Jer
    Wei, Sung-Jen
    MEDIATORS OF INFLAMMATION, 2013, 2013
  • [26] Macrophage-mediated cardiac fibrosis
    Schulze, PC
    Lee, RT
    CIRCULATION RESEARCH, 2004, 95 (06) : 552 - 553
  • [27] Studies on the immunogenicity of amyloid beta oligomers and their role in macrophage-mediated inflammation
    Dalgediene, I.
    Lasickiene, R.
    Budvytyte, R.
    Morkuniene, R.
    Borutaite, V.
    Valincius, G.
    Zvirbliene, A.
    FEBS JOURNAL, 2014, 281 : 171 - 171
  • [28] MULTISTEM® PREVENTS MACROPHAGE-MEDIATED AXONAL DIEBACK FOLLOWING SPINAL CORD INJURY
    Busch, S.
    Horn, K.
    Cuascut, F.
    Hamilton, J.
    Lehman, N.
    Ting, A.
    Mays, R.
    Silver, J.
    GLIA, 2009, 57 (13) : S79 - S80
  • [29] The Role of Lipopolysaccharide on Macrophage-Mediated Inflammatory Response in Alcoholic Chronic Pancreatitis
    Li, Yajun
    Yang, Kun
    Sun, Li
    Piao, Rongli
    Gao, Runping
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 : S66 - S66
  • [30] MECHANISMS OF MACROPHAGE-MEDIATED TUMOR CYTOLYSIS
    KEY, ME
    HOYER, L
    BUCANA, C
    HANNA, MG
    ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 1982, 146 : 265 - 310
12345