The role of exosomes derived from stem cells in nerve regeneration: A contribution to neurological repair

被引:1
|
作者
Zhang, Qiankun [1 ]
Liu, Jiale [1 ]
Wang, Wei [1 ]
Lin, Wentong [2 ]
Ahmed, Waqas [3 ]
Duan, Wenjie [1 ]
Huang, Songze [1 ]
Zhu, Zhihan [1 ]
Chen, Lukui [1 ]
机构
[1] Southern Med Univ Hosp Integrated Tradit Chinese &, Southern Med Univ, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China
[2] Chaozhou Hosp Tradit Chinese Med, Dept Orthopaed, Chaozhou, Peoples R China
[3] Southeast Univ, Sch Med, Nanjing, Jiangsu, Peoples R China
关键词
Exosome therapeutics; Nerve regeneration; Stem cells; Personalized medicine; Noncoding RNAs; TRAUMATIC BRAIN-INJURY; CIRCULAR RNAS; EXTRACELLULAR VESICLES; BIOGENESIS; DELIVERY; PROMOTE; INFLAMMATION; EXPRESSION; BIOMARKER; RESPONSES;
D O I
10.1016/j.expneurol.2024.114882
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Stem cell-derived exosomes have gained attention in regenerative medicine for their role in encouraging nerve regeneration and potential use in treating neurological diseases. These nanosized extracellular vesicles act as carriers of bioactive molecules, facilitating intercellular communication and enhancing the regenerative process in neural tissues. This comprehensive study explores the methods by which exosomes produced from various stem cells contribute to nerve healing, with a particular emphasis on their role in angiogenesis, inflammation, and cellular signaling pathways. By examining cutting-edge developments and exploring the potential of exosomes in delivering disease-specific miRNAs and proteins, we highlight their versatility in tailoring personalized therapeutic strategies. The findings presented here highlight the potential of stem cell-produced exosomes for use in neurological diseases therapy, establishing the door for future research into exosome-based neurotherapies.
引用
收藏
页数:13
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