The role of exosomes derived from stem cells in nerve regeneration: A contribution to neurological repair

被引:1
|
作者
Zhang, Qiankun [1 ]
Liu, Jiale [1 ]
Wang, Wei [1 ]
Lin, Wentong [2 ]
Ahmed, Waqas [3 ]
Duan, Wenjie [1 ]
Huang, Songze [1 ]
Zhu, Zhihan [1 ]
Chen, Lukui [1 ]
机构
[1] Southern Med Univ Hosp Integrated Tradit Chinese &, Southern Med Univ, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China
[2] Chaozhou Hosp Tradit Chinese Med, Dept Orthopaed, Chaozhou, Peoples R China
[3] Southeast Univ, Sch Med, Nanjing, Jiangsu, Peoples R China
关键词
Exosome therapeutics; Nerve regeneration; Stem cells; Personalized medicine; Noncoding RNAs; TRAUMATIC BRAIN-INJURY; CIRCULAR RNAS; EXTRACELLULAR VESICLES; BIOGENESIS; DELIVERY; PROMOTE; INFLAMMATION; EXPRESSION; BIOMARKER; RESPONSES;
D O I
10.1016/j.expneurol.2024.114882
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Stem cell-derived exosomes have gained attention in regenerative medicine for their role in encouraging nerve regeneration and potential use in treating neurological diseases. These nanosized extracellular vesicles act as carriers of bioactive molecules, facilitating intercellular communication and enhancing the regenerative process in neural tissues. This comprehensive study explores the methods by which exosomes produced from various stem cells contribute to nerve healing, with a particular emphasis on their role in angiogenesis, inflammation, and cellular signaling pathways. By examining cutting-edge developments and exploring the potential of exosomes in delivering disease-specific miRNAs and proteins, we highlight their versatility in tailoring personalized therapeutic strategies. The findings presented here highlight the potential of stem cell-produced exosomes for use in neurological diseases therapy, establishing the door for future research into exosome-based neurotherapies.
引用
收藏
页数:13
相关论文
共 50 条
  • [21] Mesenchymal stem cells derived exosomes: a new era in cardiac regeneration
    Pisheh, Hossein Rayat
    Sani, Mahsa
    STEM CELL RESEARCH & THERAPY, 2025, 16 (01)
  • [22] Exosomes from human adipose-derived stem cells promote sciatic nerve regeneration via optimizing Schwann cell function
    Chen, Jing
    Ren, Sen
    Duscher, Dominik
    Kang, Yu
    Liu, Yutian
    Wang, Cheng
    Yuan, Meng
    Guo, Guojun
    Xiong, Hewei
    Zhan, Peng
    Wang, Yang
    Machens, Hans-Guenther
    Chen, Zhenbing
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (12) : 23097 - 23110
  • [23] Exosomes Derived From Bioengineered Stem Cells Have a Major Impact on Regeneration of Ischemic Myocardium
    Gong, Min
    Wang, Min
    Wang, Jiapeng
    Wang, Yigang
    Ashraf, Muhammad
    Xu, Meifeng
    CIRCULATION, 2017, 136
  • [24] Exosomes Derived from Adipose Mesenchymal Stem Cells Promote Regeneration of Injured Liver in Minipigs
    Wang, Yue
    Piao, Chenxi
    Liu, Tao
    Lu, Xiangyu
    Ma, Yajun
    Zhang, Jiantao
    Ma, Haiyang
    Wang, Hongbin
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (12)
  • [25] Effects of Exosomes Derived from Adipose-Derived Mesenchymal Stem Cells on Pyroptosis and Regeneration of Injured Liver
    Piao, Chenxi
    Sang, Jinfang
    Kou, Zhipeng
    Wang, Yue
    Liu, Tao
    Lu, Xiangyu
    Jiao, Zhihui
    Wang, Hongbin
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (20)
  • [26] The role of mesenchymal stem cells in peripheral nerve regeneration
    Nevmerzhytska, N. M.
    Yaremenko, L. M.
    Grabovyi, O. M.
    PATHOLOGIA, 2024, 21 (02): : 170 - 176
  • [27] Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues
    Huang, Defa
    Shen, Haibin
    Xie, Fangfang
    Hu, Die
    Jin, Qing
    Hu, Yuexin
    Zhong, Tianyu
    JOURNAL OF BIOLOGICAL ENGINEERING, 2024, 18 (01):
  • [28] Role of stem cells in the regeneration and repair of peripheral nerves
    Ren, Zhiwu
    Wang, Yu
    Peng, Jiang
    Zhao, Qing
    Lu, Shibi
    REVIEWS IN THE NEUROSCIENCES, 2012, 23 (02) : 135 - 143
  • [29] The role of mesenchymal stem cells in bone repair and regeneration
    Šponer P.
    Kučera T.
    Diaz-Garcia D.
    Filip S.
    European Journal of Orthopaedic Surgery & Traumatology, 2014, 24 (3) : 257 - 262
  • [30] Platelet-rich plasma-derived exosomes boost mesenchymal stem cells to promote peripheral nerve regeneration
    Zhang, Yongyi
    Yi, Dan
    Hong, Quan
    Cao, Jiangbei
    Geng, Xiaodong
    Liu, Jinwei
    Xu, Chuang
    Cao, Mengyu
    Chen, Chao
    Xu, Shuaixuan
    Zhang, Zhen
    Li, Molin
    Zhu, Yaqiong
    Peng, Nan
    JOURNAL OF CONTROLLED RELEASE, 2024, 367 : 265 - 282