The role of exosomes derived from stem cells in nerve regeneration: A contribution to neurological repair

被引:1
|
作者
Zhang, Qiankun [1 ]
Liu, Jiale [1 ]
Wang, Wei [1 ]
Lin, Wentong [2 ]
Ahmed, Waqas [3 ]
Duan, Wenjie [1 ]
Huang, Songze [1 ]
Zhu, Zhihan [1 ]
Chen, Lukui [1 ]
机构
[1] Southern Med Univ Hosp Integrated Tradit Chinese &, Southern Med Univ, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China
[2] Chaozhou Hosp Tradit Chinese Med, Dept Orthopaed, Chaozhou, Peoples R China
[3] Southeast Univ, Sch Med, Nanjing, Jiangsu, Peoples R China
关键词
Exosome therapeutics; Nerve regeneration; Stem cells; Personalized medicine; Noncoding RNAs; TRAUMATIC BRAIN-INJURY; CIRCULAR RNAS; EXTRACELLULAR VESICLES; BIOGENESIS; DELIVERY; PROMOTE; INFLAMMATION; EXPRESSION; BIOMARKER; RESPONSES;
D O I
10.1016/j.expneurol.2024.114882
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Stem cell-derived exosomes have gained attention in regenerative medicine for their role in encouraging nerve regeneration and potential use in treating neurological diseases. These nanosized extracellular vesicles act as carriers of bioactive molecules, facilitating intercellular communication and enhancing the regenerative process in neural tissues. This comprehensive study explores the methods by which exosomes produced from various stem cells contribute to nerve healing, with a particular emphasis on their role in angiogenesis, inflammation, and cellular signaling pathways. By examining cutting-edge developments and exploring the potential of exosomes in delivering disease-specific miRNAs and proteins, we highlight their versatility in tailoring personalized therapeutic strategies. The findings presented here highlight the potential of stem cell-produced exosomes for use in neurological diseases therapy, establishing the door for future research into exosome-based neurotherapies.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] Exosomes from preconditioned mesenchymal stem cells: Tissue repair and regeneration
    Long, Ruili
    Wang, Shuai
    REGENERATIVE THERAPY, 2024, 25 : 355 - 366
  • [2] Role of skin derived stem cells in peripheral nerve regeneration
    Marchesi, C
    Pluderi, M
    Belicchi, M
    Gavina, M
    Meregalli, M
    Draghi, L
    Pisati, F
    Gaini, SM
    Bresolin, N
    Grimoldi, N
    Torrente, Y
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2005, 10 : 57 - 57
  • [3] Study on the Role and Mechanism of Exosomes Derived from Dental Pulp Stem Cells in Promoting Regeneration of Myelin Sheath in Rats with Sciatic Nerve Injury
    Chai, Ying
    Liu, Yuemin
    Liu, Zhiyang
    Wei, Wenbin
    Dong, Yabing
    Yang, Chi
    Chen, Minjie
    MOLECULAR NEUROBIOLOGY, 2024, 61 (09) : 6175 - 6188
  • [4] Adipose derived stem cells and nerve regeneration
    Faroni, Alessandro
    Smith, Richard J. P.
    Reid, Adam J.
    NEURAL REGENERATION RESEARCH, 2014, 9 (14) : 1341 - 1346
  • [5] Adipose derived stem cells and nerve regeneration
    Alessandro Faroni
    Richard JP Smith
    Adam J Reid
    NeuralRegenerationResearch, 2014, 9 (14) : 1341 - 1346
  • [6] Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair
    Zhang, Zhiwei
    Yang, Junjie
    Yan, Weiya
    Li, Yangxin
    Shen, Zhenya
    Asahara, Takayuki
    JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 5 (01):
  • [7] Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration
    Goodarzi, Parisa
    Larijani, Bagher
    Alavi-Moghadam, Sepideh
    Tayanloo-Beik, Akram
    Mohamadi-Jahani, Fereshteh
    Ranjbaran, Negar
    Payab, Moloud
    Falahzadeh, Khadijeh
    Mousavi, Maryamsadat
    Arjmand, Babak
    CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 4: STEM CELLS AND CELL BASED STRATEGIES IN REGENERATION, 2018, 1119 : 119 - 131
  • [8] Potential of adipose derived stem cell preparations in neurological repair and regeneration
    Laura Combes
    Xenia Sawkulycz
    Wen-Hui Fang
    Baoqiang Guo
    Mark Slevin
    BiophysicsReports, 2021, 7 (02) : 81 - 90
  • [9] Differentiated mesenchymal stem cells-derived exosomes immobilized in decellularized sciatic nerve hydrogels for peripheral nerve repair
    Liu, Bo
    Alimi, Olawale A.
    Wang, Yanfei
    Kong, Yunfan
    Kuss, Mitchell
    Krishnan, Mena Asha
    Hu, Guoku
    Xiao, Yi
    Dong, Jixin
    DiMaio, Dominick J.
    Duan, Bin
    JOURNAL OF CONTROLLED RELEASE, 2024, 368 : 24 - 41
  • [10] Therapeutic effect of exosomes derived from Schwann cells in the repair of peripheral nerve injury
    Wang, Jia-ling
    Huang, Qi-ming
    Hu, Dong-xia
    Zhang, Wen-jun
    LIFE SCIENCES, 2024, 357