COMBINED EFFECT OF OBETICHOLIC ACID AND BEZAFIBRATE IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND INADEQUATE RESPONSE TO OR INTOLERANCE OF URSODEOXYCHOLIC ACID: RESULTS FROM TWO PHASE 2 CLINICAL TRIALS

被引:0
|
作者
Levy, Cynthia [1 ]
Hejda, Vaclav [2 ]
Louvet, Alexandre [3 ]
Younes, Ziad [4 ]
Mendizabal, Manuel [5 ]
Bonder, Alan [6 ]
Zou, Heng [7 ]
Civitarese, Antonio [7 ]
Villamil, Alejandra [8 ]
Nevens, Frederik [9 ]
机构
[1] Univ Miami, Sch Med, Coral Gables, FL 33124 USA
[2] Univ Hosp Plzen, Plzen, Czech Republic
[3] Univ Hosp Lille, Lille, France
[4] Gastro One, Germantown, TN USA
[5] Hosp Univ Austral, Pilar, Argentina
[6] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[7] Intercept Pharmaceut Inc, Morristown, NJ USA
[8] Hosp Italiano Buenos Aires, Hepat Autoimmun Unit, Buenos Aires, DF, Argentina
[9] Univ Hosp KU Leuven, Leuven, Belgium
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
5019-C
引用
收藏
页码:E52 / E52
页数:1
相关论文
共 50 条
  • [21] Obeticholic Acid Improves Aminotransferases Early during Treatment in Patients with Primary Biliary Cholangitis Not Responding to Ursodeoxycholic Acid: A Study in Clinical Practice
    Labanca, Sara
    Cacciato, Valentina
    Borro, Paolo
    Marenco, Simona
    Pieri, Giulia
    Picciotto, Antonino
    Torres, Maria Corina Plaz
    Giannini, Edoardo G.
    IMMUNO, 2021, 1 (04): : 457 - 467
  • [22] Changes in serum bile acid levels associated with bezafibrate add-on therapy in patients with primary biliary cholangitis and inadequate biochemical response to ursodeoxycholic acid: results from the BEZURSO trial (NCT01654731)
    Corpechot, Christophe
    Chazouilleres, Olivier
    Humbert, Lydie
    Rousseau, Alexandra
    Le Gruyer, Antonia
    Habersetzer, Francois
    Mathurin, Philippe
    Goria, Odile
    Potier, Pascal
    Anne, Minello
    Silvain, Christine
    Abergel, Armando
    Debette-Gratien, Maryline
    Larrey, Dominique G.
    Roux, Olivier
    Bronowicki, Jean-Pierre
    Boursier, Jerome
    de Ledinghen, Victor
    Heurgue-Berlot, Alexandra
    Nguyen-Khac, Eric
    Zoulim, Fabien
    Ollivier-Hourmand, Isabelle
    Zarski, Jean-Pierre H.
    Nkontchou, Gisele
    Gaouar, Farid
    Simon, Tabassome
    Poupon, Raoul
    Rainteau, Dominique
    HEPATOLOGY, 2017, 66 : 168A - 168A
  • [23] Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis
    Martinez-Gili, Laura
    Pechlivanis, Alexandros
    McDonald, Julie A. K.
    Begum, Sofina
    Badrock, Jonathan
    Dyson, Jessica K.
    Jones, Rebecca
    Hirschfield, Gideon
    Ryder, Stephen D.
    Sandford, Richard
    Rushbrook, Simon
    Thorburn, Douglas
    Taylor-Robinson, Simon D.
    Crossey, Mary M. E.
    Marchesi, Julian R.
    Mells, George
    Holmes, Elaine
    Jones, David
    GUT MICROBES, 2023, 15 (01)
  • [24] OBETICHOLIC ACID AND BEZAFIBRATE IN PRIMARY BILIARY CHOLANGITIS: A COMPARATIVE EVALUATION OF EFFICACY THROUGH REAL WORLD CLINICAL PRACTICE
    Culver, Emma
    Hayden, Jennifer
    Thorburn, Douglas
    Marshall, Aileen
    Aspinall, Richard
    Dimmer, Alison
    Swabe, Jacqueline
    Hydes, Theresa
    Khakoo, Salim I.
    Williams, Elizabeth
    Maurice, James
    Burke, Niall
    Kallis, Yiannis
    Smith, Bellinda
    Patanwala, Imran
    Orrell, Michael
    Barr, Julie
    Ryder, Stephen D.
    Ellis, Tom
    Dilks, Breanne
    Bird, Samantha
    Day, Darren
    Williamson, Kate D.
    Moreea, Sulleman
    Tinker, Samantha
    Mccune, Anne
    Corless, Lynsey
    Jones, Rebecca
    Chimakurthi, Chenchu
    Miah, Zohur
    Mells, George
    Jones, David
    Hirschfield, Gideon
    Trivedi, Palak
    HEPATOLOGY, 2019, 70 : 770A - 770A
  • [25] ADDITIVE BENEFICIAL EFFECTS OF FIBRATES COMBINED WITH OBETICHOLIC ACID IN THE TREATMENT OF PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND INADEQUATE RESPONSE TO SECOND-LINE THERAPY
    Soret, Pierre-Antoine
    Lam, Laurent
    Carrat, Fabrice
    Smets, Lena
    Leroy, Vincent
    Berg, Thomas
    Carbone, Marco
    Invernizzi, Pietro
    Trivedi, Palak
    Weiler-Normann, Christina
    Alric, Laurent
    Rosa, Isabelle
    Cervoni, Jean-Paul
    Dumortier, Jerome
    Potier, Pascal
    Roux, Olivier
    Silvain, Christine
    Levy, Cynthia
    Pares, Albert
    Schramm, Christoph
    Nevens, Frederick
    Chazouilleres, Olivier
    Corpechot, Christophe
    HEPATOLOGY, 2019, 70 (06) : 1491A - 1492A
  • [26] PROMISING EFFECTS OF BEZAFIBRATE IN PATIENTS WITH PRIMARY BILIARY CIRRHOSIS AND INCOMPLETE RESPONSE TO URSODEOXYCHOLIC ACID
    Lens, S.
    Leoz, M.
    Nazal, L.
    Bruguera, M.
    Pares, A.
    JOURNAL OF HEPATOLOGY, 2011, 54 : S512 - S512
  • [27] Ustekinumab for Patients With Primary Biliary Cholangitis Who Have an Inadequate Response to Ursodeoxycholic Acid: A Proof-of-Concept Study
    Hirschfield, Gideon M.
    Gershwin, M. Eric
    Strauss, Richard
    Mayo, Marlyn J.
    Levy, Cynthia
    Zou, Bin
    Johanns, Jewel
    Nnane, Ivo P.
    Dasgupta, Bidisha
    Li, Katherine
    Selmi, Carlo
    Marschall, Hanns-Ulrich
    Jones, David
    Lindor, Keith
    HEPATOLOGY, 2016, 64 (01) : 189 - 199
  • [28] Impact of the metabolic profile on the response to ursodeoxycholic acid in patients with primary biliary cholangitis: results of the ColHai registry
    Diaz Gonzalez, Alvaro
    Gonzalez Pascual, Andrea
    Gomez-Camarero, Judith
    Gomez Dominguez, Elena
    Carlota Londono, Maria
    Vergara Gomez, Mercedes
    Ampuero, Javier
    Martinez, Javier
    Horta, Diana
    Gallego, Adolgo
    Salmeron, Javier
    Garcia-Retortillo, Montserrat
    Morillas, Rosa M.
    Andrade, Raul J.
    Turnes, Juan
    Diago, Moises
    El Hajra Martinez, Ismael
    Roget Alemany, Merce
    Hernandez Guerra, Manuel
    Quintans, Nerea
    Sala, Margarita
    Dominguez, Nuria
    Arencibia Almeida, Ana
    Crespo, Javier
    Barreira, Ana
    Salcedo, Magdalena
    Riveiro Barciela, Mar
    JOURNAL OF HEPATOLOGY, 2023, 78 : S376 - S377
  • [29] Effect of deferred or no treatment with ursodeoxycholic acid in patients with early primary biliary cholangitis
    Tanaka, Atsushi
    Hirohara, Junko
    Nakano, Toshiaki
    Yagi, Minami
    Namisaki, Tadashi
    Yoshiji, Hitoshi
    Nakanuma, Yasuni
    Takikawa, Hajime
    HEPATOLOGY RESEARCH, 2018, 48 (09) : 727 - 734
  • [30] Bezafibrate normalizes alkaline phosphatase in primary biliary cirrhosis patients with incomplete response to ursodeoxycholic acid
    Lens, Sabela
    Leoz, Maria
    Nazal, Leyla
    Bruguera, Miguel
    Pares, Albert
    LIVER INTERNATIONAL, 2014, 34 (02) : 197 - 203