COMBINED EFFECT OF OBETICHOLIC ACID AND BEZAFIBRATE IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND INADEQUATE RESPONSE TO OR INTOLERANCE OF URSODEOXYCHOLIC ACID: RESULTS FROM TWO PHASE 2 CLINICAL TRIALS

被引：0
|
作者：
Levy, Cynthia [1 ]
Hejda, Vaclav [2 ]
Louvet, Alexandre [3 ]
Younes, Ziad [4 ]
Mendizabal, Manuel [5 ]
Bonder, Alan [6 ]
Zou, Heng [7 ]
Civitarese, Antonio [7 ]
Villamil, Alejandra [8 ]
Nevens, Frederik [9 ]
机构：
[1] Univ Miami, Sch Med, Coral Gables, FL 33124 USA
[2] Univ Hosp Plzen, Plzen, Czech Republic
[3] Univ Hosp Lille, Lille, France
[4] Gastro One, Germantown, TN USA
[5] Hosp Univ Austral, Pilar, Argentina
[6] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[7] Intercept Pharmaceut Inc, Morristown, NJ USA
[8] Hosp Italiano Buenos Aires, Hepat Autoimmun Unit, Buenos Aires, DF, Argentina
[9] Univ Hosp KU Leuven, Leuven, Belgium
来源：
HEPATOLOGY | 2024年 / 79卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
5019-C
引用
下载
收藏
页码：E52 / E52
页数：1
相关论文
共 50 条
  • [1] Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid
    Hirschfield, Gideon M.
    Mason, Andrew
    Luketic, Velimir
    Lindor, Keith
    Gordon, Stuart C.
    Mayo, Marlyn
    Kowdley, Kris V.
    Vincent, Catherine
    Bodhenheimer, Henry C., Jr.
    Pares, Albert
    Trauner, Michael
    Marschall, Hanns-Ulrich
    Adorini, Luciano
    Sciacca, Cathi
    Beecher-Jones, Tessa
    Castelloe, Erin
    Boehm, Olaf
    Shapiro, David
    GASTROENTEROLOGY, 2015, 148 (04) : 751 - U347
  • [2] COST-EFFECTIVENESS ANALYSIS OF OBETICHOLIC ACID FOR THE TREATMENT OF PRIMARY BILIARY CHOLANGITIS (PBC) PATIENTS WITH INADEQUATE RESPONSE OR INTOLERANCE TO URSODEOXYCHOLIC ACID (UDCA) IN FRANCE
    Baschet, L.
    Bourguignon, S.
    Tison, A.
    VALUE IN HEALTH, 2017, 20 (09) : A556 - A556
  • [3] Determinants of the effectiveness of bezafibrate combined with ursodeoxycholic acid in patients with primary biliary cholangitis
    Matsumoto, Kosuke
    Hirohara, Junko
    Takeuchi, Akihito
    Miura, Ryo
    Asaoka, Yoshinari
    Nakano, Toshiaki
    Tanaka, Atsushi
    HEPATOLOGY RESEARCH, 2023, 53 (10) : 989 - 997
  • [4] Bezafibrate improves the effect of obeticholic acid on cholestasis in patients with primary biliary cholangitis
    Smets, Lena
    Liliane, Schrijvers
    Hannelie, Korf
    Schalk, Van der Merwe
    Frederik, Nevens
    JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E130 - E130
  • [5] Fenofibrate in Primary Biliary Cholangitis Patients With Inadequate Response to Ursodeoxycholic Acid (UDCA)
    Khaykis, Inessa
    Sherman, Alex
    Tobias, Hillel
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2018, 113 : S501 - S501
  • [6] Obeticholic Acid in Patients with primary biliary Cholangitis - Clinical Results in 2 Kaerntner Centers
    Bota, Simona
    Hucke, Florian
    Thoma, Bernd
    Flatscher, Kerstin
    Peck-Radosavljevic, Markus
    WIENER KLINISCHE WOCHENSCHRIFT, 2018, 130 : 261 - 261
  • [7] Efficacy and tolerance of obeticholic acid in patients with primary biliary cholangitis and inadequate response to ursodeoxycholic acid in real life: interim analysis of the OCARELIFE study
    Vincent, Leroy
    Corpechot, Christophe
    Dumortier, Jerome
    Alric, Laurent
    Larrey, Dominique
    Dharancy, Sebastien
    Chazouilleres, Olivier
    Heurgue-berlot, Alexandra
    Boer, Francois
    Trylesinski, Aldo
    JOURNAL OF HEPATOLOGY, 2020, 73 : S489 - S489
  • [8] Efficacy of GKT831 in patients with primary biliary cholangitis and inadequate response to ursodeoxycholic acid: Interim efficacy results of a phase 2 clinical trial
    Dalekos, George
    Invernizzi, Pietro
    Nevens, Frederik
    Hans, Van Vlierberghe
    Zigmond, Ehud
    Andrade, Raul J.
    Ben Ari, Ziv
    Heneghan, Michael
    Huang, Jonathan
    Harrison, Stephen
    Minuk, Gerald
    Joern, Schattenberg
    Moreno, Christophe
    Vierling, John
    Vincent, Catherine
    Bowlus, Christopher
    Lurie, Yoav
    Muratori, Luigi
    Niro, Grazia
    Hirschfield, Gideon
    Post, Anthony
    Zeuzem, Stefan
    Welzel, Tania
    Ch'ng, Chin Lye
    Levy, Cynthia
    Miller, Michael
    Albillos, Agustin
    Collier, Jane D.
    Corless, Lynsey
    Dieterich, Douglas
    Kremer, Andreas E.
    Papatheodoridis, George
    Romeo, David
    Silveira, Marina
    Bernstein, David
    Cohen-Naftaly, Michal
    Floreani, Annarosa
    Borg, Brian
    Carey, Elizabeth
    Hollywood, Coral
    Maliakkal, Benedict
    Marzioni, Marco
    Rabinovitz, Mordechai
    Rupp, Christian
    Sheridan, David
    Stanca, Carmen
    Swain, Mark G.
    Veitsman, Ella
    Dourakis, P. Spyridon
    Wiese, Philippe
    JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E1 - E2
  • [9] INITIAL EXPERIENCE WITH OBETICHOLIC ACID IN PRIMARY BILIARY CHOLANGITIS IN PATIENTS WITH INADEQUATE RESPONSE OR UNABLE TO TOLERATE URSODEOXICHOLIC ACID
    Maestro Prada, I
    Chaudarcas Castineira, P.
    Alvarez Sanchez, M.
    Parra Villanueva, J.
    Aguirre Losada, A. A.
    Castro Urda, J. L.
    REVISTA CASTELLANA DE GASTROENTEROLOGIA, 2021, 36 (01): : 15 - 17
  • [10] IgM response is a prognostic biomarker of primary biliary cholangitis treated with ursodeoxycholic acid and bezafibrate
    Takano, Keiko
    Saeki, Chisato
    Oikawa, Tsunekazu
    Hidaka, Akihisa
    Mizuno, Yusuke
    Ishida, Jinya
    Takakura, Kazuki
    Nakano, Masanori
    Torisu, Yuichi
    Amano, Katsushi
    Ishikawa, Tomohisa
    Zeniya, Mikio
    Tsubota, Akihito
    Saruta, Masayuki
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2020, 35 (04) : 663 - 672
12345