Duchenne muscular dystrophy (DMD), a genetic condition marked by progressive muscle degeneration, presents notable orthopaedic challenges, especially scoliosis, which deteriorates patients' quality of life by affecting sitting balance and complicating cardiac and respiratory functions. Current orthopaedic management strategies emphasize early intervention with corticosteroids to delay disease progression and the use of surgical spinal fusion to address severe scoliosis, aiming to enhance sitting balance, alleviate discomfort, and potentially extend patient lifespan. Despite advancements, optimal management requires ongoing research to refine therapeutic approaches, ensuring improved outcomes for patients with DMD. This review synthesizes recent findings on surgical and nonsurgical interventions, underscoring the importance of a multidisciplinary approach tailored to the dynamic needs of patients with DMD.
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KTH Royal Inst Technol, AlbaNova Univ Ctr, Sch Biotechnol, Div Prote, SE-10691 Stockholm, Sweden
KTH Royal Inst Technol, Sci Life Lab, Stockholm, SwedenKTH Royal Inst Technol, AlbaNova Univ Ctr, Sch Biotechnol, Div Prote, SE-10691 Stockholm, Sweden
机构:
John Walton Muscular Dystrophy Res Ctr, Newcastle Upon Tyne, Tyne & Wear, EnglandJohn Walton Muscular Dystrophy Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England
Strehle, Eugen-Matthias
Straub, Volker
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John Walton Muscular Dystrophy Res Ctr, Newcastle Upon Tyne, Tyne & Wear, EnglandJohn Walton Muscular Dystrophy Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England
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Univ Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Univ Washington, Sch Med, Seattle, WA 98105 USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Buddhe, Sujatha
Cripe, Linda
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Nationwide Childrens Hosp, Columbus, OH USA
Ohio State Univ, Columbus, OH 43210 USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Cripe, Linda
Friedland-Little, Joshua
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Univ Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Univ Washington, Sch Med, Seattle, WA 98105 USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Friedland-Little, Joshua
Kertesz, Naomi
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Nationwide Childrens Hosp, Columbus, OH USA
Ohio State Univ, Columbus, OH 43210 USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Kertesz, Naomi
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Eghtesady, Pirooz
Finder, Jonathan
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Univ Pittsburgh, Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Sch Med, Pittsburgh, PA USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Finder, Jonathan
Hor, Kan
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Nationwide Childrens Hosp, Columbus, OH USA
Ohio State Univ, Columbus, OH 43210 USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Hor, Kan
Judge, Daniel P.
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Med Univ South Carolina, Charleston, SC 29425 USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Judge, Daniel P.
Kinnett, Kathi
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Parent Project Muscular Dystrophy, Hackensack, NJ USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Kinnett, Kathi
McNally, Elizabeth M.
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Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
McNally, Elizabeth M.
Raman, Subha
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Ohio State Univ, Columbus, OH 43210 USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Raman, Subha
Thompson, W. Reid
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Johns Hopkins Univ Hosp, Baltimore, MD 21287 USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Thompson, W. Reid
Wagner, Kathryn R.
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Johns Hopkins Univ, Sch Med, Kennedy Krieger Inst, Baltimore, MD USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Wagner, Kathryn R.
Olson, Aaron K.
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Univ Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
Univ Washington, Sch Med, Seattle, WA 98105 USAUniv Washington, Seattle Childrens Hosp, 4800 Sand Point Way NE, Seattle, WA 98105 USA
机构:
Childrens Hosp, Clin Res Unit, Eastern Ontario Res Inst, Ottawa, ON, Canada
Childrens Hosp Eastern Ontario, Div Respirol, Ottawa, ON, Canada
Univ Ottawa, Fac Med, Ottawa, ON, CanadaChildrens Hosp, Clin Res Unit, Eastern Ontario Res Inst, Ottawa, ON, Canada
Proulx, Frederic
Blinder, Henrietta
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Childrens Hosp, Clin Res Unit, Eastern Ontario Res Inst, Ottawa, ON, CanadaChildrens Hosp, Clin Res Unit, Eastern Ontario Res Inst, Ottawa, ON, Canada
Blinder, Henrietta
Barrowman, Nick
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Childrens Hosp, Clin Res Unit, Eastern Ontario Res Inst, Ottawa, ON, Canada
Univ Ottawa, Fac Med, Ottawa, ON, CanadaChildrens Hosp, Clin Res Unit, Eastern Ontario Res Inst, Ottawa, ON, Canada
Barrowman, Nick
Katz, Sherri L.
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Childrens Hosp, Clin Res Unit, Eastern Ontario Res Inst, Ottawa, ON, Canada
Childrens Hosp Eastern Ontario, Div Respirol, Ottawa, ON, Canada
Univ Ottawa, Fac Med, Ottawa, ON, CanadaChildrens Hosp, Clin Res Unit, Eastern Ontario Res Inst, Ottawa, ON, Canada