KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma

被引：0
|
作者：
Yu Shuang-Ni
Ma Yi-Hui
Zhao Wu-Gan
Jin Xiang-Lan
Yang Hai-Yan
Liu Ping-Ping
Chen Jie
机构：
来源：
慢性疾病与转化医学（英文） | 2016年 / 2卷 / 04期
关键词：
Pancreatic ductal adenocarcinoma; KRAS; Noncoding RNAs; microRNAs; Long noncoding RNAs;
D O I：
暂无
中图分类号：
R735.9 [胰腺肿瘤];
学科分类号：
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection ofKRAS-driven PDAC. Here, we summarize our studies and review current reports on research investigatingKRAS-related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC.
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