KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma

被引：0
|
作者：
Yu Shuang-Ni
Ma Yi-Hui
Zhao Wu-Gan
Jin Xiang-Lan
Yang Hai-Yan
Liu Ping-Ping
Chen Jie
机构：
来源：
慢性疾病与转化医学（英文） | 2016年 / 2卷 / 04期
关键词：
Pancreatic ductal adenocarcinoma; KRAS; Noncoding RNAs; microRNAs; Long noncoding RNAs;
D O I：
暂无
中图分类号：
R735.9 [胰腺肿瘤];
学科分类号：
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection ofKRAS-driven PDAC. Here, we summarize our studies and review current reports on research investigatingKRAS-related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC.
引用
收藏
相关论文
共 50 条
  • [11] Critical role of KRAS mutation in pancreatic ductal adenocarcinoma
    Fan, Zhiyao
    Fan, Kun
    Yang, Chao
    Huang, Qiuyi
    Gong, Yitao
    Cheng, He
    Jin, Kaizhou
    Liu, Chen
    Ni, Quanxing
    Yu, Xianjun
    Luo, Guopei
    TRANSLATIONAL CANCER RESEARCH, 2018, 7 (06) : 1728 - 1736
  • [12] PATHOGENIC KRAS MUTATIONS PROFILE IN PANCREATIC DUCTAL ADENOCARCINOMA
    Iacob, Razvan
    Dima, Simona
    Sorop, Andrei
    Manea, Ioana
    Ionescu, Victor S.
    Spiridon, Andreea G.
    Stoica, Bianca
    Bunduc, Stefania
    Chiosa, Andrei
    Cazacu, Irina M.
    Croitoru, Vlad M.
    Chelaru, Raluca
    Iacob, Speranta
    Becheanu, Gabriel
    Dumbrava, Mona
    Herlea, Vlad
    Croitoru, Adina E.
    Csiki, Irma Eva
    Ceafalan, Laura C.
    Popescu, Irinel
    Gheorghe, Cristian
    GASTROENTEROLOGY, 2023, 164 (06) : S802 - S803
  • [13] Plasma KRAS as a biomarker for pancreatic ductal adenocarcinoma (PDAC).
    Krantz, Benjamin A.
    Tsui, Dana
    Lowery, Maeve Aine
    Capanu, Marinela
    Yu, Kenneth H.
    Kelsen, David Paul
    Gedvilaite, Erika
    Zhang, Liguo
    Selcuklu, S. Duygu
    You, Daoqi
    Pernicka, Jennifer S. Golia
    Do, Richard K. G.
    Iacobuzio-Donahue, Christine A.
    O'Reilly, Eileen Mary
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (04)
  • [14] Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma
    Feigin, Michael E.
    Garvin, Tyler
    Bailey, Peter
    Waddell, Nicola
    Chang, David K.
    Kelley, David R.
    Shuai, Shimin
    Gallinger, Steven
    McPherson, John D.
    Grimmond, Sean M.
    Khurana, Ekta
    Stein, Lincoln D.
    Biankin, Andrew V.
    Schatz, Michael C.
    Tuveson, David A.
    NATURE GENETICS, 2017, 49 (06) : 825 - +
  • [15] Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma
    Feigin, Michael E.
    Garvin, Tyler
    Bailey, Peter
    Waddell, Nicola
    Chang, David K.
    Shuai, Shimin
    Gallinger, Steven
    McPherson, John D.
    Grimmond, Sean M.
    Khurana, Ekta
    Stein, Lincoln D.
    Biankin, Andrew V.
    Schatz, Michael C.
    Tuveson, David A.
    CANCER RESEARCH, 2016, 76
  • [16] KRAS-related miR-143 expression is associated with lymph node involvement and correlates with outcome in pancreatic adenocarcinoma patients
    Lavacchi, Daniele
    Polvani, Simone
    Taddei, Antonio
    Scolari, Federico
    Messerini, Luca
    Caliman, Enrico
    Moraldi, Luca
    Guidolin, Alessia
    Grazi, Gian Luca
    Galli, Andrea
    Pillozzi, Serena
    Antonuzzo, Lorenzo
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [17] Non-coding RNAs in Pancreatic Ductal Adenocarcinoma
    Gong, Ruining
    Jiang, Yueping
    FRONTIERS IN ONCOLOGY, 2020, 10
  • [18] KRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progression
    Zhang, Zining
    Zhang, Heng
    Liao, Xiang
    Tsai, Hsiang-i
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023, 11
  • [19] Oncogenic KRAS triggers metabolic reprogramming in pancreatic ductal adenocarcinoma
    Shen, Xuqing
    Niu, Ningning
    Xue, Jing
    JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE, 2023, 11 (04) : 322 - 329
  • [20] Concentrations of trace elements and KRAS mutations in pancreatic ductal adenocarcinoma
    Gomez-Tomas, Alvaro
    Pumarega, Jose
    Alguacil, Juan
    Amaral, Andre F. S.
    Malats, Nuria
    Pallares, Natalia
    Gasull, Magda
    Porta, Miquel
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2019, 60 (08) : 693 - 703
12345