Synthesis and Antioxidant Activity of Furan Derivatives Containing a 1,3,4-Oxadiazole Ring

被引：0
|
作者：
Aghekyan, A. A. [1 ]
Panosyan, H. A. [1 ]
Buniatyan, Zh. M. [1 ]
Muradyan, R. E. [1 ]
Mkryan, G. G. [1 ]
机构：
[1] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 04期
关键词：
furan; hydrazide; phosphoryl chloride; cyclization; 1,3,4-oxadiazole;
D O I：
10.1134/S1070428024040146
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Methyl 5-aminomethylfuran-2-carboxylates reacted with methylamine to give 5-aminomethylN-methylfuran-2-carboxamides, and their hydrolysis afforded the corresponding carboxylic acids. The reaction of methyl 5-aminomethylfuran-2-carboxylates with hydrazine hydrate produced hydrazides which were acylated with benzoyl or 2-furoyl chloride and then subjected to heterocyclization to obtain furan derivatives containing a 1,3,4-oxadiazole ring. The target products were also synthesized in one step by reacting 5-aminomethylfuran-2-carbohydrazides with acid chlorides in the presence of phosphoryl chloride.
引用
收藏
页码：655 / 663
页数：9
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