Synthesis and Antioxidant Activity of Furan Derivatives Containing a 1,3,4-Oxadiazole Ring

被引：0

作者：

Aghekyan, A. A. ^{[1
]}

Panosyan, H. A. ^{[1
]}

Buniatyan, Zh. M. ^{[1
]}

Muradyan, R. E. ^{[1
]}

Mkryan, G. G. ^{[1
]}

机构：

[1] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 04期

关键词：

furan; hydrazide; phosphoryl chloride; cyclization; 1,3,4-oxadiazole;

D O I：

10.1134/S1070428024040146

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methyl 5-aminomethylfuran-2-carboxylates reacted with methylamine to give 5-aminomethylN-methylfuran-2-carboxamides, and their hydrolysis afforded the corresponding carboxylic acids. The reaction of methyl 5-aminomethylfuran-2-carboxylates with hydrazine hydrate produced hydrazides which were acylated with benzoyl or 2-furoyl chloride and then subjected to heterocyclization to obtain furan derivatives containing a 1,3,4-oxadiazole ring. The target products were also synthesized in one step by reacting 5-aminomethylfuran-2-carbohydrazides with acid chlorides in the presence of phosphoryl chloride.

引用

页码：655 / 663

页数：9

共 50 条

[21] Synthesis, in silico analysis and antidepressant activity of 1,3,4-oxadiazole derivatives
Gatphoh, Banylla Felicity Dkhar
Aggarwal, Natasha Naval
Kumar, S. Madan
Kumar, M. Vijay
Revanasiddappa, B. C.
BANGLADESH JOURNAL OF PHARMACOLOGY, 2022, 17 (01) : 14 - 21
[22] SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL 1,3,4-OXADIAZOLE DERIVATIVES
ELSAMII, ZKA
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 1992, 53 (02) : 143 - 146
[23] Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives
Yu, Fuqiang
Guan, Aiying
Li, Mengru
Hu, Lan
Li, Xiaowu
CHINESE CHEMICAL LETTERS, 2018, 29 (06) : 915 - 918
[24] Synthesis and anti tuberculostatic activity of novel 1,3,4-oxadiazole derivatives
Yar, M. Shahar
Siddiqui, A. Ahmad
Ali, M. Ashraf
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2007, 54 (01) : 5 - 8
[25] Synthesis, Crystal Structure and Antifungal Activity of New Furan-1,3,4-oxadiazole Carboxamide Derivatives
Sun Yue
Yang Zi-Hui
Gu Wen
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2022, 41 (02) : 2202098 - 2202104
[26] Synthesis and antibacterial activity of 1,3,4-oxadiazole substituted pyrimidine derivatives
Andrews, B.
Komathi, K.
Mohan, S.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2018, 57 (04): : 591 - 597
[27] Synthesis and evaluation of antimicrobial activity of novel 1,3,4-oxadiazole derivatives
Mohite, P. B.
Bhaskar, V. H.
ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY, 2011, 3 (02): : 117 - 124
[28] Synthesis, Molecular Docking, and Anticonvulsant Activity of 1,3,4-Oxadiazole Derivatives
Balachandra, Anagha
Deshpande, Shridhar Narayan
Raj, Anjana
Revanasiddappa, Bistuvalli C.
JOURNAL OF HEALTH AND ALLIED SCIENCES NU, 2025, 15 (01): : 63 - 69
[29] Design, Synthesis, and Antifungal Activity of Novel Thiochromanone Derivatives Containing 1,3,4-Oxadiazole Skeleton
Sun, Xiaoyang
Feng, Jiajia
Li, Shengbin
Feng, Siran
Liu, Zhenming
Song, Yali
Qiao, Xiaoqiang
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 39 (04) : 1037 - 1043
[30] Stereoselective synthesis and fungicidal activities of (E)-α(methoxyimino)-benzeneacetate derivatives containing 1,3,4-oxadiazole ring
Li, Y
Liu, H
Zhang, HQ
Yang, XP
Liu, ZJ
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (08) : 2278 - 2282

← 1 2 3 4 5 →