Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury

被引：104
|
作者：
Zhao W.-K. [1 ]
Zhou Y. [2 ,3 ]
Xu T.-T. [1 ]
Wu Q. [4 ]
机构：
[1] Department of Health Care Ward, First Affiliated Hospital of Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin
[2] Department of Pathophysiology, Xuzhou Medical University, Jiangsu province, Xuzhou
[3] Laboratory of Clinical and Experimental Pathology, Xuzhou Medical University, Jiangsu province, Xuzhou
[4] Department of Physiology, Xuzhou Medical University, Jiangsu province, Xuzhou
来源：
Oxidative Medicine and Cellular Longevity | 2021年 / 2021卷
基金：
中国国家自然科学基金;
关键词：
Oxidative stress - Lipids - Oxidation;
D O I：
10.1155/2021/9929687
中图分类号：
学科分类号：
摘要：
Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane lipid peroxidation due to redox imbalances and excessive ROS accumulation, damaging the integrity of cell membranes. Ferroptosis is mainly characterized by mitochondrial shrinkage, increased density of bilayer membranes, and the accumulation of lipid peroxidation. Myocardial ischemia-reperfusion injury (MIRI) is an unavoidable risk event for acute myocardial infarction. Ferroptosis is closely associated with MIRI, and this relationship is discussed in detail here. This review systematically summarizes the process of ferroptosis and the latest research progress on the role of ferroptosis in MIRI to provide new ideas for the prevention and treatment of MIRI. © 2021 Wei-kun Zhao et al.
引用
收藏
相关论文
共 50 条
  • [31] Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death
    Hwang, Ji-Won
    Park, Jae-Hyun
    Park, Bong-Woo
    Kim, Hyeok
    Kim, Jin-Ju
    Sim, Woo-Sup
    Mishchenko, Natalia P.
    Fedoreyev, Sergey A.
    Vasileva, Elena A.
    Ban, Kiwon
    Park, Hun-Jun
    Baek, Sang-Hong
    [J]. ANTIOXIDANTS, 2021, 10 (10)
  • [32] Current Status and Prospects of Research on Ischemia-Reperfusion Injury and Ferroptosis
    Hou, Lin
    Li, Xiaodong
    Su, Chang
    Chen, Kailin
    Qu, Maoxing
    [J]. FRONTIERS IN ONCOLOGY, 2022, 12
  • [33] Targeting Ferroptosis as a Promising Therapeutic Strategy for Ischemia-Reperfusion Injury
    Pan, Yihang
    Wang, Xueke
    Liu, Xiwang
    Shen, Lihua
    Chen, Qixing
    Shu, Qiang
    [J]. ANTIOXIDANTS, 2022, 11 (11)
  • [34] The Protective Effect of Cyanidin-3-Glucoside on Myocardial Ischemia-Reperfusion Injury through Ferroptosis
    Shan, Xin
    Lv, Zhi-Yang
    Yin, Meng-Jiao
    Chen, Jing
    Wang, Jie
    Wu, Qi-Nan
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 2021
  • [35] Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury
    Li, Xinye
    Ma, Ning
    Xu, Juping
    Zhang, Yanchi
    Yang, Pan
    Su, Xin
    Xing, Yanfeng
    An, Na
    Yang, Fan
    Zhang, Guoxia
    Zhang, Lijing
    Xing, Yanwei
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 2021
  • [36] Acute myocardial infarction and myocardial ischemia-reperfusion injury: a comparison
    Hashmi, Satwat
    Al-Salam, Suhail
    [J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (08): : 8786 - 8796
  • [37] Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice
    Lv, Bingjie
    Zhou, Jin
    He, Shaolin
    Zheng, Yuqi
    Yang, Wenlin
    Liu, Shangwei
    Liu, Chengxing
    Wang, Boyuan
    Li, Dazhu
    Lin, Jibin
    [J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2022, (179):
  • [38] Broadening horizons: The role of ferroptosis in myocardial ischemia–reperfusion injury
    Ke Zhao
    Xiaoshu Chen
    Yujing Bian
    Zhou Zhou
    Xijin Wei
    Juan Zhang
    [J]. Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, 396 : 2269 - 2286
  • [39] Myocardial Ischemia/Reperfusion Injury: Mechanism and Targeted Treatment for Ferroptosis
    Deng, Yun
    Chen, Qiaoling
    Wang, Tianyu
    Wang, Shuangcui
    Li, Ruoyun
    Wang, Yuli
    Zhang, Jiaqi
    Gan, Jiali
    Guo, Maojuan
    [J]. ANATOLIAN JOURNAL OF CARDIOLOGY, 2024, 28 (03): : 133 - 141
  • [40] Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury
    Miyamoto, Hiroko Deguchi
    Ikeda, Masataka
    Ide, Tomomi
    Tadokoro, Tomonori
    Furusawa, Shun
    Abe, Ko
    Ishimaru, Kosei
    Enzan, Nobuyuki
    Sada, Masashi
    Yamamoto, Taishi
    Matsushima, Shouji
    Koumura, Tomoko
    Yamada, Ken-ichi
    Imai, Hirotaka
    Tsutsui, Hiroyuki
    [J]. JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022, 7 (08): : 801 - 820
12345