Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury

被引：122
|
作者：
Zhao W.-K. [1 ]
Zhou Y. [2 ,3 ]
Xu T.-T. [1 ]
Wu Q. [4 ]
机构：
[1] Department of Health Care Ward, First Affiliated Hospital of Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin
[2] Department of Pathophysiology, Xuzhou Medical University, Jiangsu province, Xuzhou
[3] Laboratory of Clinical and Experimental Pathology, Xuzhou Medical University, Jiangsu province, Xuzhou
[4] Department of Physiology, Xuzhou Medical University, Jiangsu province, Xuzhou
来源：
Oxidative Medicine and Cellular Longevity | 2021年 / 2021卷
基金：
中国国家自然科学基金;
关键词：
Oxidative stress - Lipids - Oxidation;
D O I：
10.1155/2021/9929687
中图分类号：
学科分类号：
摘要：
Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane lipid peroxidation due to redox imbalances and excessive ROS accumulation, damaging the integrity of cell membranes. Ferroptosis is mainly characterized by mitochondrial shrinkage, increased density of bilayer membranes, and the accumulation of lipid peroxidation. Myocardial ischemia-reperfusion injury (MIRI) is an unavoidable risk event for acute myocardial infarction. Ferroptosis is closely associated with MIRI, and this relationship is discussed in detail here. This review systematically summarizes the process of ferroptosis and the latest research progress on the role of ferroptosis in MIRI to provide new ideas for the prevention and treatment of MIRI. © 2021 Wei-kun Zhao et al.
引用
收藏
相关论文
共 50 条
  • [21] Sphingolipid therapy in myocardial ischemia-reperfusion injury
    Gundewar, Susheel
    Lefer, David J.
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2008, 1780 (03): : 571 - 576
  • [22] Status of myocardial antioxidants in ischemia-reperfusion injury
    Dhalla, NS
    Elmoselhi, AB
    Hata, T
    Makino, N
    CARDIOVASCULAR RESEARCH, 2000, 47 (03) : 446 - 456
  • [23] Effect of dexmedetomidine on myocardial ischemia-reperfusion injury
    Chen, Shoulin
    Hua, Fuzhou
    Lu, Jun
    Jiang, Yu
    Tang, Yanhua
    Tao, Lei
    Zou, Bing
    Wu, Qinghua
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (11): : 21166 - 21172
  • [24] Is there a role for apoptosis in myocardial ischemia-reperfusion injury?
    Kingma, JG
    Bergeron, S
    FASEB JOURNAL, 1999, 13 (04): : A19 - A19
  • [25] Myocardial ischemia-reperfusion injury and the influence of inflammation 
    Algoet, Michiel
    Janssens, Stefan
    Himmelreich, Uwe
    Gsell, Willy
    Pusovnik, Matic
    van den Eynde, Jef
    Oosterlinck, Wouter
    TRENDS IN CARDIOVASCULAR MEDICINE, 2023, 33 (06) : 357 - 366
  • [26] The role of neutrophils in myocardial ischemia-reperfusion injury
    Jordan, JE
    Zhao, ZQ
    Vinten-Johansen, J
    CARDIOVASCULAR RESEARCH, 1999, 43 (04) : 860 - 878
  • [27] Curcumin attenuates myocardial ischemia-reperfusion injury
    Liu, Kun
    Chen, Honglin
    You, Qing-Sheng
    Ye, Qing
    Wang, Fei
    Wang, Shuo
    Zhang, Shuang-Long
    Yu, Kang-Jun
    Lu, Qi
    ONCOTARGET, 2017, 8 (67) : 112051 - 112059
  • [28] The challenges of lower extremity ischemia-reperfusion injury
    Belkin, M
    VASCULAR SURGERY, 1996, 30 (02): : 85 - 88
  • [29] Purinergic signaling in myocardial ischemia-reperfusion injury
    Zhuang, Yi
    Yu, Mei-ling
    Lu, Sheng-feng
    PURINERGIC SIGNALLING, 2023, 19 (01) : 229 - 243
  • [30] The Protective of Baicalin on Myocardial Ischemia-Reperfusion Injury
    Liu, Xiaoli
    Zhang, Shanshan
    Xu, Chaoyue
    Sun, Yongchao
    Sui, Shujian
    Zhang, Zhaohua
    Luan, Yun
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2020, 21 (13) : 1386 - 1393
12345