Galectin-1 overexpression induces normal fibroblasts translate into cancer-associated fibroblasts and attenuates the sensitivity of anlotinib in lung cancer

被引：1
|
作者：
Zhang, Lei [1 ]
Chen, Wenbang [1 ]
Li, Xiaojun [1 ]
Wang, Gengming [2 ]
Xing, Fubao [1 ]
Zhu, Xiao [1 ]
机构：
[1] Bengbu Med Coll, Dept Thorac Surg, Affiliated Hosp 1, 287 Changhuai Rd, Bengbu 233004, Anhui, Peoples R China
[2] Bengbu Med Coll, Dept Radiotherapy, Affiliated Hosp 1, Bengbu, Anhui, Peoples R China
来源：
CELL ADHESION & MIGRATION | 2024年 / 18卷 / 01期
关键词：
Condition mediums; HUVEC; TGF-beta; 1; tube formation; alpha-SMA; EXPRESSION; MICROENVIRONMENT; MELANOMA; VEGF;
D O I：
10.1080/19336918.2024.2335881
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We aimed to investigate galectin-1 overexpression induces normal fibroblasts (NFs) translates into cancer-associated fibroblasts (CAFs). Galectin-1 overexpression was conducted in Human embryonic lung fibroblasts (HFL1) cell. The motilities of H1299 and A549 cells were measured. Human umbilical vein endothelial cell (HUVEC) proliferation and tube formation ability were assessed. Tumor volume and tumor weight was recorded. Cells motilities were increased, while apoptosis rates were decreased after CMs co-cultured. B-cell lymphoma-2 (Bcl-2) expression level was increased, while Bcl2-associatedX (Bax) and cleaved-caspase3 decreased. CMs treatment enhanced HUVEC proliferation and tube formation. Tumor volume and weight in CMs treated mice were increased, and the sensitivity of anlotinib in co-cultured cells was decreased. Our results revealed that galectin-1 overexpression induced NFs translated into CAFs.
引用
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页码：1 / 11
页数：11
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