Galectin-1 overexpression induces normal fibroblasts translate into cancer-associated fibroblasts and attenuates the sensitivity of anlotinib in lung cancer

被引：0
|
作者：
Zhang, Lei [1 ]
Chen, Wenbang [1 ]
Li, Xiaojun [1 ]
Wang, Gengming [2 ]
Xing, Fubao [1 ]
Zhu, Xiao [1 ]
机构：
[1] Bengbu Med Coll, Dept Thorac Surg, Affiliated Hosp 1, 287 Changhuai Rd, Bengbu 233004, Anhui, Peoples R China
[2] Bengbu Med Coll, Dept Radiotherapy, Affiliated Hosp 1, Bengbu, Anhui, Peoples R China
来源：
CELL ADHESION & MIGRATION | 2024年 / 18卷 / 01期
关键词：
Condition mediums; HUVEC; TGF-beta; 1; tube formation; alpha-SMA; EXPRESSION; MICROENVIRONMENT; MELANOMA; VEGF;
D O I：
10.1080/19336918.2024.2335881
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We aimed to investigate galectin-1 overexpression induces normal fibroblasts (NFs) translates into cancer-associated fibroblasts (CAFs). Galectin-1 overexpression was conducted in Human embryonic lung fibroblasts (HFL1) cell. The motilities of H1299 and A549 cells were measured. Human umbilical vein endothelial cell (HUVEC) proliferation and tube formation ability were assessed. Tumor volume and tumor weight was recorded. Cells motilities were increased, while apoptosis rates were decreased after CMs co-cultured. B-cell lymphoma-2 (Bcl-2) expression level was increased, while Bcl2-associatedX (Bax) and cleaved-caspase3 decreased. CMs treatment enhanced HUVEC proliferation and tube formation. Tumor volume and weight in CMs treated mice were increased, and the sensitivity of anlotinib in co-cultured cells was decreased. Our results revealed that galectin-1 overexpression induced NFs translated into CAFs.
引用
收藏
页码：1 / 11
页数：11
相关论文
共 50 条
  • [31] The roles of cancer-associated fibroblasts in stemness maintenance of lung cancer cells
    Lin, Chih-An
    Ho, Chao-Chi
    Chen, Jeremy J. W.
    [J]. CANCER RESEARCH, 2015, 75
  • [32] Interaction between cancer-associated fibroblasts and apoptotic cancer cells inhibits the migration and invasion of lung cancer cells and cancer-associated fibroblasts preventing the development of metastasis
    Kim, Hee Ja
    Yang, Kyungwon
    Kim, Kiyoon
    Kang, Jihee Lee
    [J]. CANCER IMMUNOLOGY RESEARCH, 2022, 10 (12)
  • [33] The role of cancer-associated fibroblasts in esophageal cancer
    Wang, Jiangfeng
    Zhang, Guangyu
    Wang, Jianbo
    Wang, Lu
    Huang, Xiaochen
    Cheng, Yufeng
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2016, 14
  • [34] Advances of cancer-associated fibroblasts in liver cancer
    Hao Peng
    Erwei Zhu
    Yewei Zhang
    [J]. Biomarker Research, 10
  • [35] Cancer-Associated Fibroblasts: Perspectives in Cancer Therapy
    Prakash, Jai
    [J]. TRENDS IN CANCER, 2016, 2 (06): : 277 - 279
  • [36] Advances of cancer-associated fibroblasts in liver cancer
    Peng, Hao
    Zhu, Erwei
    Zhang, Yewei
    [J]. BIOMARKER RESEARCH, 2022, 10 (01)
  • [37] YAP1 plays a key role of the conversion of normal fibroblasts into cancer-associated fibroblasts that contribute to prostate cancer progression
    Shen, Tianyu
    Li, Yang
    Zhu, Shimiao
    Yu, Jianpeng
    Zhang, Boya
    Chen, Xuanrong
    Zhang, Zheng
    Ma, Yuan
    Niu, Yuanjie
    Shang, Zhiqun
    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2020, 39 (01)
  • [38] Cancer-Associated Fibroblasts: Implications for Cancer Therapy
    Maia, Ana
    Wiemann, Stefan
    [J]. CANCERS, 2021, 13 (14)
  • [39] The role of cancer-associated fibroblasts in esophageal cancer
    Jiangfeng Wang
    Guangyu Zhang
    Jianbo Wang
    Lu Wang
    Xiaochen Huang
    Yufeng Cheng
    [J]. Journal of Translational Medicine, 14
  • [40] The Role of Cancer-Associated Fibroblasts in Ovarian Cancer
    Zhang, Mo
    Chen, Zhixian
    Wang, Yan
    Zhao, Hongbo
    Du, Yan
    [J]. CANCERS, 2022, 14 (11)
12345