Comprehensive Collection of Whole-Slide Images and Genomic Profiles for Patients with Bladder Cancer

被引:0
|
作者
Xu, Pei-Hang [1 ,2 ]
Li, Tianqi [2 ,3 ,4 ]
Qu, Fengmei [5 ]
Tian, Mingkang [5 ]
Wang, Jun [6 ,7 ,8 ]
Gan, Hualei [2 ,3 ,4 ]
Ye, Dingwei [1 ,2 ]
Ren, Fei [9 ]
Shen, Yijun [1 ,2 ]
机构
[1] Fudan Univ, Dept Urol, Shanghai Canc Ctr, Shanghai, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
[3] Fudan Univ, Shanghai Canc Ctr, Dept Pathol, Shanghai, Peoples R China
[4] Fudan Univ, Inst Pathol, Shanghai 200032, Peoples R China
[5] Jinfeng Lab, Chongqing 401329, Peoples R China
[6] Sun Yat Sen Univ, Canc Ctr, Dept Urol, Guangzhou, Peoples R China
[7] State Key Lab Oncol Southern China, Guangzhou, Peoples R China
[8] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou, Peoples R China
[9] Chinese Acad Sci, Inst Comp Technol, State Key Lab Processors, Beijing 100190, Peoples R China
关键词
ALIGNMENT;
D O I
10.1038/s41597-024-03526-3
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Bladder cancer is one of the leading causes of cancer-related mortality in the urinary system. Understanding genomic information is important in the treatment and prognosis of bladder cancer, but the current method used to identify mutations is time-consuming and labor-intensive. There are now many novel and convenient ways to predict cancerous genomics from pathological slides. However, the publicly available datasets are limited, especially for Asian populations. In this study, we developed a dataset consisting of 75 Asian cases of bladder cancers and 112 Whole-Slide Images with one to two images obtained for each patient. This dataset provides information on the most frequently and clinically significant mutated genes derived by whole-exome sequencing in these patients. This dataset will facilitate exploration and development of novel diagnostic and therapeutic technologies for bladder cancer.
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页数:8
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