Synthesis of acridones via Ir(<sc>iii</sc>)-catalyzed amination annulation of oxazoles with anthranils

被引：0
|
作者：
Zhou, Han-Yi [1 ,2 ]
Dong, Lin [1 ,2 ]
机构：
[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug, Educ Minist & Sichuan Prov, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 20期
关键词：
METAL-FREE SYNTHESIS; BOND-CLEAVAGE; FUNCTIONALIZATION; CHALLENGES; DESIGN;
D O I：
10.1039/d4ob00377b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented Ir(iii)-catalyzed C-H activation/amination/annulation of 2-phenyloxazoles with anthranils for the highly selective preparation of acridone derivatives in one-pot under controlled conditions is reported. This protocol is characterized by atom economy and high regioselectivity. A wide range of anthranils with 2-phenyloxazoles were well tolerated and afforded the desired products in moderate to good yields, in which the anthranil serves as a convenient amination reagent.
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收藏
页码：4036 / 4040
页数：5
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