CD44: a cancer stem cell marker and therapeutic target in leukemia treatment

被引：10
|
作者：
Wu, Shuang [1 ,2 ]
Tan, Yicheng [1 ,2 ,3 ]
Li, Fanfan [2 ,3 ,4 ]
Han, Yixiang [2 ,3 ,5 ]
Zhang, Shenghui [1 ,2 ,3 ,4 ]
Lin, Xiaofei [4 ]
机构：
[1] Wenzhou Med Univ, Lab Anim Ctr, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Inst Hematol, Wenzhou, Zhejiang, Peoples R China
[3] Wenzhou Key Lab Hematol, Wenzhou, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Dept Hematol, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
[5] Wenzhou Med Univ, Cent Lab, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
中国国家自然科学基金;
关键词：
CD44; leukemia; adhesion; migration; homing; differentiation; biomarkers; clinical application; ACUTE MYELOID-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; HYALURONAN-CD44; INTERACTION; ADHESION MOLECULES; SOLUBLE CD44; BONE-MARROW; POOR-PROGNOSIS; ERM PROTEINS; SERUM CD44; EXPRESSION;
D O I：
10.3389/fimmu.2024.1354992
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. CD44 can mediate the interaction between leukemic stem cells and the surrounding extracellular matrix, thereby inducing a cascade of signaling pathways to regulate their various behaviors. In this review, we focus on the impact of CD44s/CD44v as biomarkers in leukemia development and discuss the current research and prospects for CD44-related interventions in clinical application.
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收藏
页数：16
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