CD44: a cancer stem cell marker and therapeutic target in leukemia treatment

被引：10
|
作者：
Wu, Shuang [1 ,2 ]
Tan, Yicheng [1 ,2 ,3 ]
Li, Fanfan [2 ,3 ,4 ]
Han, Yixiang [2 ,3 ,5 ]
Zhang, Shenghui [1 ,2 ,3 ,4 ]
Lin, Xiaofei [4 ]
机构：
[1] Wenzhou Med Univ, Lab Anim Ctr, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Inst Hematol, Wenzhou, Zhejiang, Peoples R China
[3] Wenzhou Key Lab Hematol, Wenzhou, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Dept Hematol, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
[5] Wenzhou Med Univ, Cent Lab, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
中国国家自然科学基金;
关键词：
CD44; leukemia; adhesion; migration; homing; differentiation; biomarkers; clinical application; ACUTE MYELOID-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; HYALURONAN-CD44; INTERACTION; ADHESION MOLECULES; SOLUBLE CD44; BONE-MARROW; POOR-PROGNOSIS; ERM PROTEINS; SERUM CD44; EXPRESSION;
D O I：
10.3389/fimmu.2024.1354992
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. CD44 can mediate the interaction between leukemic stem cells and the surrounding extracellular matrix, thereby inducing a cascade of signaling pathways to regulate their various behaviors. In this review, we focus on the impact of CD44s/CD44v as biomarkers in leukemia development and discuss the current research and prospects for CD44-related interventions in clinical application.
引用
收藏
页数：16
相关论文
共 50 条
  • [21] NEAT1 is Required for the Expression of the Liver Cancer Stem Cell Marker CD44
    Koyama, Shigemi
    Tsuchiya, Hiroyuki
    Amisaki, Masataka
    Sakaguchi, Hiromi
    Honjo, Soichiro
    Fujiwara, Yoshiyuki
    Shiota, Goshi
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (06)
  • [22] CD44 as a cancer stem cell marker and its prognostic value in patients with ovarian carcinoma
    Bartakova, Alena
    Michalova, Kveta
    Presl, Jiri
    Vlasak, Pavel
    Kostun, Jan
    Bouda, Jiri
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2018, 38 (01) : 110 - 114
  • [23] Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target
    Yan, Yongmin
    Zuo, Xiangsheng
    Wei, Daoyan
    STEM CELLS TRANSLATIONAL MEDICINE, 2015, 4 (09) : 1033 - 1043
  • [24] CD90 a potential cancer stem cell marker and a therapeutic target
    Shaikh, Muhammad Vaseem
    Kala, Manika
    Nivsarkar, Manish
    CANCER BIOMARKERS, 2016, 16 (03) : 301 - 307
  • [25] Immunohistochemical markers in breast cancer brain metastases: the role of the cancer stem cell marker CD44 in prognosis
    Gama, J.
    Oliveira Caetano, R.
    Gama, J.
    Figueiredo, P.
    Rebelo, O.
    Cipriano, M. A.
    VIRCHOWS ARCHIV, 2021, 479 (SUPPL 1) : S5 - S5
  • [26] Potential stem cell marker CD44 is constitutively expressed in permanent cell lines of head and neck cancer
    Pries, Ralph
    Wittkopf, Nadine
    Trenkle, Thomas
    Nitsch, Stefan M.
    Wollenberg, Barbara
    IN VIVO, 2008, 22 (01): : 89 - 92
  • [27] Clinical significance of putative cancer stem cell marker CD44 in different histological subtypes of lung cancer
    Roudi, Raheleh
    Madjd, Zahra
    Korourian, Alireza
    Mehrazma, Mitra
    Molanae, Saadat
    Sabet, Mehrdad Nasrollahzadeh
    Shariftabrizi, Ahmad
    CANCER BIOMARKERS, 2014, 14 (06) : 457 - 467
  • [28] CD44 as potential therapeutic target for medulloblastoma metastasis
    Qi, Dan
    Wang, Fengfei
    Fonkem, Ekokobe
    Huang, Jason H.
    Wu, Erxi
    CANCER RESEARCH, 2019, 79 (13)
  • [29] CD44 and CD133 as Cancer Stem Cell Markers for Gastric Cancer
    Lee, Hyun-Joo
    Choi, Young-Sil
    Kim, Sung-Joo
    Moon, Hyoun Jong
    JOURNAL OF GASTRIC CANCER, 2010, 10 (03) : 99 - 105
  • [30] CD44, hyaluronan, the hematopoietic stem cell, and leukemia-initiating cells
    Zoeller, Margot
    FRONTIERS IN IMMUNOLOGY, 2015, 6
12345