Characterization of DYRK2(dual-specificity tyrosine-phosphorylation-regulated kinase 2) from Zebrafish(Dario rerio)

被引：0
|
作者：
孙威 [1 ,2 ]
谭训刚 [1 ]
张培军 [1 ]
张玉青 [1 ]
徐永立 [1 ]
机构：
[1] Institute of Oceanology,Chinese Academy of Sciences
[2] Graduate School,Chinese Academy of
来源：
ChineseJournalofOceanologyandLimnology | 2010年 / 28卷 / 04期
关键词：
D O I：
暂无
中图分类号：
S917.4 [水产动物学];
学科分类号：
摘要：
Proteins of the DYRK(dual-specificity tyrosine-phosphorylation-regulated kinase) family are characterized by the presence of a conserved kinase domain and N-terminal DH box.DYRK2 is involved in regulating key developmental and cellular processes,such as neurogenesis,cell proliferation,cytokinesis,and cellular differentiation.Herein,we report that the ortholog of DYRK2 found in zebrafish shares about 70% identity with that of human,mouse,and chick.RT-PCR showed that DYRK2 is expressed maternally and zygotically.In-situ hybridization results show that DYRK2 is expressed in somite cells that will develop into muscles.Our results provide preliminary evidence for investigating the in-vivo function of DYRK2 in zebrafish muscle development.
引用
收藏
页码：720 / 724
页数：5
相关论文
共 50 条
  • [31] Dual-specificity tyrosine phosphorylation-regulated kinase 1A does not require tyrosine phosphorylation for activity in vitro
    Adayev, Tatyana
    Chen-Hwang, Mo-Chou
    Murakami, Noriko
    Lee, Eric
    Bolton, David C.
    Hwang, Yu-Wen
    BIOCHEMISTRY, 2007, 46 (25) : 7614 - 7624
  • [32] Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer
    Yuan, Kai
    Li, Zhaoxing
    Kuang, Wenbin
    Wang, Xiao
    Ji, Minghui
    Chen, Weijiao
    Ding, Jiayu
    Li, Jiaxing
    Min, Wenjian
    Sun, Chengliang
    Ye, Xiuquan
    Lu, Meiling
    Wang, Liping
    Ge, Haixia
    Jiang, Yuzhang
    Hao, Haiping
    Xiao, Yibei
    Yang, Peng
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [33] Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome
    Murakami, Noriko
    Xie, Wen
    Lu, Renne Chen
    Chen-Hwang, Mo-Chou
    Wieraszko, Andrzej
    Hwang, Yu Wen
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (33) : 23712 - 23724
  • [34] Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase lA (DYRK1A) in Down-Syndrome-Derived Fibroblasts
    Kawakubo, Takashi
    Mori, Ryotaro
    Shirotani, Keiro
    Iwata, Nobuhisa
    Asai, Masashi
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2017, 40 (03) : 327 - 333
  • [35] Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule
    Wu, Yi-Wen
    Huangfu, Wei-Chun
    Lin, Tony Eight
    Peng, Chao-Hsiang
    Tu, Huang-Ju
    Sung, Ting-Yi
    Sung, Tzu-Ying
    Yen, Shih-Chung
    Pan, Shiow-Lin
    Hsu, Kai-Cheng
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 259
  • [36] Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)
    Rosenthal, Andrew S.
    Tanega, Cordelle
    Shen, Min
    Mott, Bryan T.
    Bougie, James M.
    Nguyen, Dac-Trung
    Misteli, Tom
    Auld, Douglas S.
    Maloney, David J.
    Thomas, Craig J.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (10) : 3152 - 3158
  • [37] Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
    Oi, Ami
    Katayama, Syouichi
    Hatano, Naoya
    Sugiyama, Yasunori
    Kameshita, Isamu
    Sueyoshi, Noriyuki
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 482 (02) : 239 - 245
  • [38] Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity
    Hutterer, Corina
    Milbradt, Jens
    Hamilton, Stuart
    Zaja, Mirko
    Leban, Johann
    Henry, Christophe
    Vitt, Daniel
    Steingruber, Mirjam
    Sonntag, Eric
    Zeittraeger, Isabel
    Bahsi, Hanife
    Stamminger, Thomas
    Rawlinson, William
    Strobl, Stefan
    Marschall, Manfred
    ANTIVIRAL RESEARCH, 2017, 143 : 113 - 121
  • [39] Dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) as a novel marker in T1 high-grade and T2 bladder cancer patients receiving neoadjuvant chemotherapyDYRK2 is associated with survival in bladder cancer
    Shunichiro Nomura
    Yasutomo Suzuki
    Ryo Takahashi
    Mika Terasaki
    Ryoji Kimata
    Yasuhiro Terasaki
    Tsutomu Hamasaki
    Go Kimura
    Akira Shimizu
    Yukihiro Kondo
    BMC Urology, 15
  • [40] DUAL-SPECIFICITY TYROSINE PHOSPHORYLATION-REGULATED KINASE 2 AS A NOVEL MARKER IN BLADDER CANCER PATIENTS RECEIVING NEOADJUVANT CHEMOTHERAPY
    Nomura, Shunichiro
    Suzuki, Yasutomo
    Akatsuka, Jun
    Takahashi, Ryo
    Terasaki, Mika
    Kimata, Ryoji
    Matsuzawa, Ichiro
    Hamasaki, Tsutomu
    Kimura, Go
    Shimizu, Akira
    Kondo, Yukihiro
    JOURNAL OF UROLOGY, 2014, 191 (04): : E235 - E235
12345