Characterization of DYRK2(dual-specificity tyrosine-phosphorylation-regulated kinase 2) from Zebrafish(Dario rerio)

被引：0
|
作者：
孙威 [1 ,2 ]
谭训刚 [1 ]
张培军 [1 ]
张玉青 [1 ]
徐永立 [1 ]
机构：
[1] Institute of Oceanology,Chinese Academy of Sciences
[2] Graduate School,Chinese Academy of
来源：
ChineseJournalofOceanologyandLimnology | 2010年 / 28卷 / 04期
关键词：
D O I：
暂无
中图分类号：
S917.4 [水产动物学];
学科分类号：
摘要：
Proteins of the DYRK(dual-specificity tyrosine-phosphorylation-regulated kinase) family are characterized by the presence of a conserved kinase domain and N-terminal DH box.DYRK2 is involved in regulating key developmental and cellular processes,such as neurogenesis,cell proliferation,cytokinesis,and cellular differentiation.Herein,we report that the ortholog of DYRK2 found in zebrafish shares about 70% identity with that of human,mouse,and chick.RT-PCR showed that DYRK2 is expressed maternally and zygotically.In-situ hybridization results show that DYRK2 is expressed in somite cells that will develop into muscles.Our results provide preliminary evidence for investigating the in-vivo function of DYRK2 in zebrafish muscle development.
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页码：720 / 724
页数：5
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