T cell receptor signaling and cell immunotherapy

被引：0

作者：

Linsong Zhang ^{[1
]}

Xinyi Xu ^{[2
]}

Xiaoshan Shi ^{[1
]}

Chenqi Xu ^{[2
]}

机构：

[1] Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences

[2] State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of

来源：

National Science Open | 2024年 / 3卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R392.12 [免疫细胞生物学];

学科分类号：

摘要：

As the major sensor of adaptive immune system, T cell receptor(TCR) can recognize diverse antigens and initiate specific immune responses against invading pathogens and cancer cells. Understanding the mechanisms of TCR signaling has led to the development of engineered T cell therapies, which have extensive applications in the treatment of diseases such as cancer, infection and autoimmunity. Here, we review the current understanding of antigen-induced TCR signaling and discuss its applications in T cell therapies.

引用

页码：156 / 171

页数：16

共 50 条

[31] Fine-tuning T cell receptor signaling to control T cell development
Fu, Guo
Rybakin, Vasily
Brzostek, Joanna
Paster, Wolfgang
Acuto, Oreste
Gascoigne, Nicholas R. J.
TRENDS IN IMMUNOLOGY, 2014, 35 (07) : 311 - 318
[32] Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population
Mailer, Reiner K. W.
Gistera, Anton
Polyzos, Konstantinos A.
Ketelhuth, Daniel F. J.
Hansson, Goran K.
SCIENTIFIC REPORTS, 2017, 7
[33] T-cell receptor signaling and growth pathways in T-cell tumors
Admirand, JH
Herling, M
Patel, K
Rassidakis, GZ
Oyarzo, MP
Medeiros, LJ
Jones, D
LABORATORY INVESTIGATION, 2005, 85 : 220A - 220A
[34] Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population
Reiner K. W. Mailer
Anton Gisterå
Konstantinos A. Polyzos
Daniel F. J. Ketelhuth
Göran K. Hansson
Scientific Reports, 7
[35] The role of T cell receptor signaling thresholds in guiding T cell fate decisions
Zikherman, Julie
Au-Yeung, Byron
CURRENT OPINION IN IMMUNOLOGY, 2015, 33 : 43 - 48
[36] T-cell receptor signaling and growth pathways in T-cell tumors
Admirand, JH
Herling, M
Patel, K
Rassidakis, G
Oyarzo, MP
Medeiros, LJ
Jones, D
MODERN PATHOLOGY, 2005, 18 : 220A - 220A
[37] T cell immunotherapy
McKee, Mark D.
Fichera, Allesandro
Nishimura, Michael I.
FRONTIERS IN BIOSCIENCE-LANDMARK, 2007, 12 : 919 - 932
[38] MHC-restricted T cell receptor signaling is required for αβ TCR replacement of the pre T cell receptor
Croxford, Andrew L.
Akilli-Ozturk, Oezlem
Rieux-Laucat, Frederic
Foerster, Irmgard
Waisman, Ari
Buch, Thorsten
EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (02) : 391 - 399
[39] T-cell receptor affinity in the age of cancer immunotherapy
Hoffmann, Michele M.
Slansky, Jill E.
MOLECULAR CARCINOGENESIS, 2020, 59 (07) : 862 - 870
[40] Chimeric antigen receptor T cell immunotherapy for gynecological malignancies
Gao, Yajuan
He, Jing
Wang, Jing
Xu, Haiou
Ma, Lin
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2025, 209

← 1 2 3 4 5 →