T cell receptor signaling and cell immunotherapy

被引：0

作者：

Linsong Zhang ^{[1
]}

Xinyi Xu ^{[2
]}

Xiaoshan Shi ^{[1
]}

Chenqi Xu ^{[2
]}

机构：

[1] Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences

[2] State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of

来源：

National Science Open | 2024年 / 3卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R392.12 [免疫细胞生物学];

学科分类号：

摘要：

As the major sensor of adaptive immune system, T cell receptor(TCR) can recognize diverse antigens and initiate specific immune responses against invading pathogens and cancer cells. Understanding the mechanisms of TCR signaling has led to the development of engineered T cell therapies, which have extensive applications in the treatment of diseases such as cancer, infection and autoimmunity. Here, we review the current understanding of antigen-induced TCR signaling and discuss its applications in T cell therapies.

引用

页码：156 / 171

页数：16

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