Fibrinogen's potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer's disease
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作者:
Vishal Singh
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Department of Pharmacology,Physiology and Neurosciences,Rutgers-New Jersey Medical SchoolDepartment of Pharmacology,Physiology and Neurosciences,Rutgers-New Jersey Medical School
Vishal Singh
[1
]
Arnab Choudhury
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Department of Pharmacology,Physiology and Neurosciences,Rutgers-New Jersey Medical SchoolDepartment of Pharmacology,Physiology and Neurosciences,Rutgers-New Jersey Medical School
Arnab Choudhury
[1
]
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Hyung Jin Ahn
[1
,2
]
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[1] Department of Pharmacology,Physiology and Neurosciences,Rutgers-New Jersey Medical School
Alzheimer’s disease(AD) stands out as the primary manifestation of age-related dementia, portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau. However, from a clinical standpoint, AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological mechanism.
机构:
Univ Amsterdam, Swammerdam Inst Life Sci, Ctr Neurosci, Amsterdam, Netherlands
NEURAD Grad Sch, Marie Curie Early Stage Training Program, Gottingen, GermanyCase Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
Marlatt, Michael W.
Lucassen, Paul J.
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Univ Amsterdam, Swammerdam Inst Life Sci, Ctr Neurosci, Amsterdam, NetherlandsCase Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
Lucassen, Paul J.
Perry, George
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Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
Univ Texas San Antonio, Coll Sci, San Antonio, TX USACase Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
Perry, George
Smith, Mark A.
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Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USACase Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
Smith, Mark A.
Zhu, Xiongwei
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Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USACase Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA