Fibrinogen's potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer's disease
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作者:
Vishal Singh
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Department of Pharmacology,Physiology and Neurosciences,Rutgers-New Jersey Medical SchoolDepartment of Pharmacology,Physiology and Neurosciences,Rutgers-New Jersey Medical School
Vishal Singh
[1
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Arnab Choudhury
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Department of Pharmacology,Physiology and Neurosciences,Rutgers-New Jersey Medical SchoolDepartment of Pharmacology,Physiology and Neurosciences,Rutgers-New Jersey Medical School
Arnab Choudhury
[1
]
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Hyung Jin Ahn
[1
,2
]
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[1] Department of Pharmacology,Physiology and Neurosciences,Rutgers-New Jersey Medical School
Alzheimer’s disease(AD) stands out as the primary manifestation of age-related dementia, portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau. However, from a clinical standpoint, AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological mechanism.
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Univ Pittsburgh, Kenneth P Dietrich Sch Arts & Sci, Dept Neurosci, Pittsburgh, PA USAUniv Pittsburgh, Kenneth P Dietrich Sch Arts & Sci, Dept Neurosci, Pittsburgh, PA USA
de Quevedo, Joao Luis Barichello
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Leffa, Douglas Teixeira
Pascoal, Tharick A.
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Univ Pittsburgh, Med Sch, Dept Psychiat, Pittsburgh, PA USA
Univ Pittsburgh, Med Sch, Dept Neurol, Pittsburgh, PA USA
3811 Ohara St, Pittsburgh, PA 15213 USAUniv Pittsburgh, Kenneth P Dietrich Sch Arts & Sci, Dept Neurosci, Pittsburgh, PA USA