Degradation and racemization of zopiclone enantiomers in plasma and partially aqueous solutions

被引：27
|
作者：
Fernandez, C
Gimenez, F
Mayrargue, J
Thuillier, A
Farinotti, R
机构：
[1] HOP LA PITIE SALPETRIERE,SERV PHARM,UNITE DOSAGE MEDICAMENTS,F-75013 PARIS,FRANCE
[2] UNIV PARIS 11,FAC PHARM,DEPT CLIN PHARM,F-92290 CHATENAY MALABRY,FRANCE
[3] UNIV PARIS 11,FAC PHARM,DEPT CHIM ORGAN,CNRS 1843,F-92290 CHATENAY MALABRY,FRANCE
来源：
CHIRALITY | 1995年 / 7卷 / 04期
关键词：
chirality; cyclopyrrolone; isomers; racemization; stability; zopiclone;
D O I：
10.1002/chir.530070413
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We investigated the degradation and racemization of zopiclone (ZOP) enantiomers in plasma and partially aqueous solutions (ethanol:phosphate buffer). Degradation and racemization increased with increasing pH and temperature. Degradation products were identified by means of mass spectrometry, which revealed hydrolysis of the carbamate function and opening of the pyrrolidone ring. In plasma, neither degradation nor racemization occurred after 6 months of storage at -20 degrees C and subsequent extraction. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码：267 / 271
页数：5
相关论文
共 50 条
  • [41] Radiolytic degradation of malathion and lindane in aqueous solutions
    Mohamed, K. A.
    Basfar, A. A.
    Al-Kahtani, H. A.
    Al-Hamad, K. S.
    RADIATION PHYSICS AND CHEMISTRY, 2009, 78 (11) : 994 - 1000
  • [42] DEGRADATION OF TAUROMUSTINE (TCNU) IN AQUEOUS-SOLUTIONS
    LOFTSSON, T
    BALDVINSDOTTIR, J
    ACTA PHARMACEUTICA NORDICA, 1992, 4 (03): : 129 - 132
  • [43] Sonolytic degradation of acetic acid in aqueous solutions
    Findik, S.
    Guenduez, G.
    ULTRASONICS SONOCHEMISTRY, 2007, 14 (02) : 157 - 162
  • [44] Degradation of dyes in aqueous solutions by the Fenton process
    Xu, XR
    Li, HB
    Wang, WH
    Gu, JD
    CHEMOSPHERE, 2004, 57 (07) : 595 - 600
  • [45] Electrochemical Degradation of Tetracycline on BDD in Aqueous Solutions
    Chen, Te-San
    Tsai, Ren-Wei
    Chen, Yu-Syuan
    Huang, Kuo-Lin
    INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, 2014, 9 (12): : 8422 - 8434
  • [46] Electrochemical Detection and Degradation of Acetaminophen in Aqueous Solutions
    Chen, Te-San
    Huang, Kuo-Lin
    INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, 2012, 7 (08): : 6877 - 6892
  • [47] DEGRADATION REACTION OF POLYPYRROLE IN AQUEOUS ACIDIC SOLUTIONS
    SHIM, YB
    PARK, DS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 204 : 173 - COLL
  • [48] KINETICS OF AMOXYCILLIN DEGRADATION IN AQUEOUS-SOLUTIONS
    ZIA, H
    SHALCHIAN, N
    BORHANIAN, F
    CANADIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1977, 12 (03): : 80 - 83
  • [49] Degradation of aqueous solutions of camphor by heterogeneous photocatalysis
    Sirtori, C
    Altvater, PK
    de Freitas, AM
    Peralta-Zamora, PG
    JOURNAL OF HAZARDOUS MATERIALS, 2006, 129 (1-3) : 110 - 115
  • [50] Degradation of polyacrylamide and its derivatives in aqueous solutions
    Kurenkov, VF
    Hartan, HG
    Lobanov, FI
    RUSSIAN JOURNAL OF APPLIED CHEMISTRY, 2002, 75 (07) : 1039 - 1050
12345