Degradation and racemization of zopiclone enantiomers in plasma and partially aqueous solutions

被引：27
|
作者：
Fernandez, C
Gimenez, F
Mayrargue, J
Thuillier, A
Farinotti, R
机构：
[1] HOP LA PITIE SALPETRIERE,SERV PHARM,UNITE DOSAGE MEDICAMENTS,F-75013 PARIS,FRANCE
[2] UNIV PARIS 11,FAC PHARM,DEPT CLIN PHARM,F-92290 CHATENAY MALABRY,FRANCE
[3] UNIV PARIS 11,FAC PHARM,DEPT CHIM ORGAN,CNRS 1843,F-92290 CHATENAY MALABRY,FRANCE
来源：
CHIRALITY | 1995年 / 7卷 / 04期
关键词：
chirality; cyclopyrrolone; isomers; racemization; stability; zopiclone;
D O I：
10.1002/chir.530070413
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We investigated the degradation and racemization of zopiclone (ZOP) enantiomers in plasma and partially aqueous solutions (ethanol:phosphate buffer). Degradation and racemization increased with increasing pH and temperature. Degradation products were identified by means of mass spectrometry, which revealed hydrolysis of the carbamate function and opening of the pyrrolidone ring. In plasma, neither degradation nor racemization occurred after 6 months of storage at -20 degrees C and subsequent extraction. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码：267 / 271
页数：5
相关论文
共 50 条
  • [21] Sonochemical degradation of ofloxacin in aqueous solutions
    Hapeshi, E.
    Achilleos, A.
    Papaioannou, A.
    Valanidou, L.
    Xekoukoulotakis, N. P.
    Mantzavinos, D.
    Fatta-Kassinos, D.
    WATER SCIENCE AND TECHNOLOGY, 2010, 61 (12) : 3141 - 3146
  • [22] Ultrasonic degradation of sulfadiazine in aqueous solutions
    Lastre-Acosta, Arlen Mabel
    Cruz-Gonzalez, German
    Nuevas-Paz, Lauro
    Jauregui-Haza, Ulises Javier
    Silva Costa Teixeira, Antonio Carlos
    ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2015, 22 (02) : 918 - 925
  • [23] Degradation kinetics of benzonatate in aqueous solutions
    Lin, WJ
    Chen, YY
    Chen, RRL
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 176 (02) : 179 - 186
  • [24] Ultrasonic degradation of sulfadiazine in aqueous solutions
    Arlen Mabel Lastre-Acosta
    Germán Cruz-González
    Lauro Nuevas-Paz
    Ulises Javier Jáuregui-Haza
    Antonio Carlos Silva Costa Teixeira
    Environmental Science and Pollution Research, 2015, 22 : 918 - 925
  • [25] Plasma electroradiolysis of aqueous solutions
    Polyakov, O. V.
    Badalyan, A. M.
    Bakhturova, L. F.
    HIGH ENERGY CHEMISTRY, 2009, 43 (03) : 189 - 195
  • [26] DEGRADATION OF PIRROLIDINOMETHYLOXYTETRACYCLINE IN AQUEOUS-SOLUTIONS
    TOROK, I
    FEKETE, J
    PAAL, TL
    MAGYAR KEMIAI FOLYOIRAT, 1980, 86 (10): : 478 - 479
  • [27] Plasma electroradiolysis of aqueous solutions
    O. V. Polyakov
    A. M. Badalyan
    L. F. Bakhturova
    High Energy Chemistry, 2009, 43 : 189 - 195
  • [28] SALT EFFECTS ON RACEMIZATION SPEED FOR BIPHENYLDICARBOXYLIC ACID DIAN IONS IN AQUEOUS SOLUTIONS
    BERNTSSO.P
    SVENSK KEMISK TIDSKRIFT, 1967, 79 (10): : 562 - &
  • [29] Thermodynamic parameters of some partially fluorinated and hydrogenated amphiphilic enantiomers and their racemates in aqueous solution
    Olutas, E. Berna
    Acimis, M.
    JOURNAL OF CHEMICAL THERMODYNAMICS, 2012, 47 : 144 - 153
  • [30] Degradation of α-Naphthol by Plasma in Aqueous Solution
    高锦章
    胡中爱
    王晓艳
    侯经国
    卢小泉
    康敬万
    Plasma Science & Technology, 2001, (01) : 641 - 646
12345