Degradation and racemization of zopiclone enantiomers in plasma and partially aqueous solutions

被引：27
|
作者：
Fernandez, C
Gimenez, F
Mayrargue, J
Thuillier, A
Farinotti, R
机构：
[1] HOP LA PITIE SALPETRIERE,SERV PHARM,UNITE DOSAGE MEDICAMENTS,F-75013 PARIS,FRANCE
[2] UNIV PARIS 11,FAC PHARM,DEPT CLIN PHARM,F-92290 CHATENAY MALABRY,FRANCE
[3] UNIV PARIS 11,FAC PHARM,DEPT CHIM ORGAN,CNRS 1843,F-92290 CHATENAY MALABRY,FRANCE
来源：
CHIRALITY | 1995年 / 7卷 / 04期
关键词：
chirality; cyclopyrrolone; isomers; racemization; stability; zopiclone;
D O I：
10.1002/chir.530070413
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We investigated the degradation and racemization of zopiclone (ZOP) enantiomers in plasma and partially aqueous solutions (ethanol:phosphate buffer). Degradation and racemization increased with increasing pH and temperature. Degradation products were identified by means of mass spectrometry, which revealed hydrolysis of the carbamate function and opening of the pyrrolidone ring. In plasma, neither degradation nor racemization occurred after 6 months of storage at -20 degrees C and subsequent extraction. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码：267 / 271
页数：5
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