BENZOTRIAZOLE-ASSISTED SYNTHESIS OF NOVEL MANNICH-BASES FROM KETONES AND DIVERSE ALDEHYDES

被引：49

作者：

KATRITZKY, AR

HARRIS, PA

机构：

[1] Department of Chemistry, University of Florida, Gainesville

来源：

TETRAHEDRON | 1990年 / 46卷 / 03期

关键词：

D O I：

10.1016/S0040-4020(01)81378-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A wide variety of β-amino ketones are prepared in moderate to good yields by the reaction of the lithium enolates of cyclohexanone, acetophenone, α-tetralone and camphor with the readily available adducts from an aldehyde or ketone, an amine and benzotriazole. Some diastereoselectivity is observed when the benzotriazole adduct is derived from benzaldehyde. © 1990.

引用

页码：987 / 996

页数：10

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