BENZOTRIAZOLE-ASSISTED SYNTHESIS OF NOVEL MANNICH-BASES FROM KETONES AND DIVERSE ALDEHYDES

被引：49
|
作者：
KATRITZKY, AR
HARRIS, PA
机构：
[1] Department of Chemistry, University of Florida, Gainesville
来源：
TETRAHEDRON | 1990年 / 46卷 / 03期
关键词：
D O I：
10.1016/S0040-4020(01)81378-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A wide variety of β-amino ketones are prepared in moderate to good yields by the reaction of the lithium enolates of cyclohexanone, acetophenone, α-tetralone and camphor with the readily available adducts from an aldehyde or ketone, an amine and benzotriazole. Some diastereoselectivity is observed when the benzotriazole adduct is derived from benzaldehyde. © 1990.
引用
收藏
页码：987 / 996
页数：10
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