PROGESTERONE AND ESTRADIOL INCREASE CYTOSOLIC CA2+ IN SINGLE-RAT HEPATOCYTES

被引：32
|
作者：
SANCHEZBUENO, A [1 ]
SANCHO, MJ [1 ]
COBBOLD, PH [1 ]
机构：
[1] UNIV BASQUE COUNTRY,FAC SCI,DEPT BIOCHEM,E-48080 BILBAO,SPAIN
来源：
BIOCHEMICAL JOURNAL | 1991年 / 280卷
基金：
英国惠康基金;
关键词：
D O I：
10.1042/bj2800273
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Progesterone (300-400-mu-M) and oestradiol (25-200-mu-M) induce a prompt rise in the cytosolic free Ca2+ concentration (free Ca) in single rat hepatocytes, but testosterone, cortisol and dexamethasone do not. These increases are dependent on the presence of extracellular Ca2+. Both progesterone and oestradiol block phenylephrine-induced free Ca oscillations. These data suggest a certain specificity of the response of free Ca to steroids and may explain some of the non-genomic effects of these steroids on hepatocytes.
引用
收藏
页码：273 / 276
页数：4
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