Transcriptional regulation by promoters with enhancer function

被引：37
|
作者：
Dao, Lan T. M. [1 ]
Spicuglia, Salvatore [2 ,3 ]
机构：
[1] Vinmec Res Inst Stem Cell & Gene Technol VRISG, Hanoi, Vietnam
[2] Aix Marseille Univ, INSERM, TAGC, UMR, Marseille, France
[3] Equipe Labellisee Ligue Canc, Paris, France
来源：
TRANSCRIPTION-AUSTIN | 2018年 / 9卷 / 05期
关键词：
Enhancer; promoter; Epromoter; gene regulation; reporter-assay; CRISPR/Cas9;
D O I：
10.1080/21541264.2018.1486150
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Promoters with enhancer activity have been described recently. In this point of view, we will discuss current findings highlighting the commonality of this type of regulatory elements, their genetic and epigenetic characteristics, their potential biological roles in the regulation of gene expression and the underlining molecular mechanisms.
引用
收藏
页码：307 / 314
页数：8
相关论文
共 50 条
  • [21] Transcriptional regulation of oct-6 by the Schwann cell enhancer
    Basheer, Noorjahan Jagalur
    NEURON GLIA BIOLOGY, 2007, 2 : S135 - S136
  • [22] Transcriptional regulation of the Ig heavy chain locus by the 3′ enhancer
    Kim, EC
    Schaffer, A
    Zan, H
    Cerutti, A
    Casali, P
    FASEB JOURNAL, 2001, 15 (04): : A697 - A697
  • [23] The function and regulation of CCAAT/enhancer binding protein ε
    Cheng, Shaowen
    Yang, Jian
    Wang, Yudie
    Xian, Lina
    Hu, Zhihua
    Zou, Lingyun
    EUROPEAN JOURNAL OF INFLAMMATION, 2023, 21
  • [24] TANDEM KAPPA IMMUNOGLOBULIN PROMOTERS ARE EQUALLY ACTIVE IN THE PRESENCE OF THE KAPPA-ENHANCER - IMPLICATIONS FOR MODELS OF ENHANCER FUNCTION
    ATCHISON, ML
    PERRY, RP
    CELL, 1986, 46 (02) : 253 - 262
  • [25] REGULATORY ELEMENTS Metazoan promoters: emerging characteristics and insights into transcriptional regulation
    Lenhard, Boris
    Sandelin, Albin
    Carninci, Piero
    NATURE REVIEWS GENETICS, 2012, 13 (04) : 233 - 245
  • [26] HS2 enhancer function is blocked by a transcriptional terminator inserted between the enhancer and the promoter
    Ling, JH
    Ainol, L
    Zhang, L
    Yu, XP
    Pi, WH
    Tuan, D
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (49) : 51704 - 51713
  • [27] Transcriptional regulation of fis operon involves a module of multiple coupled promoters
    Nasser, W
    Rochman, M
    Muskhelishvili, G
    EMBO JOURNAL, 2002, 21 (04): : 715 - 724
  • [28] TRANSCRIPTIONAL REGULATION OF THE MAJOR PROMOTERS OF THE HUMAN IGF-II GENE
    HOLTHUIZEN, P
    VANDIJK, MA
    RODENBURG, RJT
    KOONENREEMST, AMCB
    SUSSENBACH, JS
    MOLECULAR REPRODUCTION AND DEVELOPMENT, 1993, 35 (04) : 391 - 393
  • [29] Transcriptional regulation of the ABCG5/ABCG8 promoters
    Freeman, LA
    Remaley, AT
    Bark, S
    Brewer, B
    Santamarina-Fojo, S
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (05) : A76 - A76
  • [30] Transcriptional regulation of Iγ promoters through binding of NF-κB
    Dryer, RL
    Belser, JA
    Sinquett, FL
    Covey, LR
    FASEB JOURNAL, 2003, 17 (07): : C193 - C193
12345