GROWTH-CONTROL OF INFLUENZA-A VIRUS BY M1 PROTEIN - ANALYSIS OF TRANSFECTANT VIRUSES CARRYING THE CHIMERIC M-GENE

被引：39
|
作者：
YASUDA, J
BUCHER, DJ
ISHIHAMA, A
机构：
[1] NATL INST GENET, DEPT MOLEC GENET, MISHIMA, SHIZUOKA 411, JAPAN
[2] GRAD UNIV ADV STUDIES, SCH LIFE SCI, MISHIMA, SHIZUOKA 411, JAPAN
[3] NEW YORK MED COLL, DEPT MICROBIOL, VALHALLA, NY 10595 USA
来源：
JOURNAL OF VIROLOGY | 1994年 / 68卷 / 12期
关键词：
D O I：
10.1128/JVI.68.12.8141-8146.1994
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Analysis of fast-growing reassortants (AWM viruses) of influenza A virus produced by mixed infection with a fast-growing WSN strain and a slowly growing Aichi strain indicated that the M gene plays a role in the regulation of virus growth rate at an early step of infection (J. Yasuda, T. Toyoda, M. Nakayama, and A. Ishihama, Arch. Virol. 133:283-294, 1993). To determine which of the two M gene products, M1 or M2, is responsible for the growth rate control, one recombinant WSN virus (CWA) clone possessing a chimeric M gene (WSN M1-Aichi M2) was generated by using an improved reverse genetics and transfection system. The recombinant CWA virus retained the phenotype of both large plaque formation and early onset of virus growth. This indicates that the WSN M1 protein is responsible for rapid virus growth.
引用
收藏
页码：8141 / 8146
页数：6
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