MECHANISM OF INFLUENZA-VIRUS TRANSCRIPTION INHIBITION BY MATRIX (M1) PROTEIN

被引：27
|
作者：
HANKINS, RW
NAGATA, K
KATO, A
ISHIHAMA, A
机构：
[1] NATL INST GENET,DEPT MOLEC GENET,MISHIMA,SHIZUOKA 411,JAPAN
[2] HLTH SCI RES INST,MICROBIOL LAB,HODOGAYA KU,YOKOHAMA 240,JAPAN
来源：
RESEARCH IN VIROLOGY | 1990年 / 141卷 / 03期
关键词：
Influenza virus; Matrix protein; Protein NP; Transcription; Initiation; Inhibition;
D O I：
10.1016/0923-2516(90)90002-Z
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The mechanism by which influenza virus matrix (M1) protein inhibits viral RNA (vRNA) transcription was investigated. Evidence has been generated that M1 protein inhibits the steps of vRNA transcription initiation and reinitiation more effectively than that of RNA chain elongation. The vRNA-associated nucleocapsid protein (NP) appears to be critical for this inhibition, implying that M1 protein binds to the ribonucleoprotein complex (RNP) through NP. © 1990.
引用
收藏
页码：305 / 314
页数：10
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