SYNTHESIS OF OLIGONUCLEOTIDES VIA PHOSPHORAMIDITE APPROACH UTILIZING 2-DIPHENYLMETHYLSILYLETHYL (DPSE) AS A PHOSPHORUS PROTECTING GROUP

被引：13

作者：

RAVIKUMAR, VT

WYRZYKIEWICZ, TK

COLE, DL

机构：

[1] Isis Pharmaceuticals, Carlsbad, CA 92008

来源：

TETRAHEDRON | 1994年 / 50卷 / 31期

关键词：

D O I：

10.1016/S0040-4020(01)85503-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Diphenylmethylsilylethyl (DPSE) is a new protecting group for internucleotidic bonds in the synthesis of oligodeoxyribo nucleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild beta-fragmentation conditions using aqueous ammonium hydroxide.

引用

页码：9255 / 9266

页数：12

共 47 条

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