SYNTHESIS OF OLIGONUCLEOTIDES VIA PHOSPHORAMIDITE APPROACH UTILIZING 2-DIPHENYLMETHYLSILYLETHYL (DPSE) AS A PHOSPHORUS PROTECTING GROUP

被引：13
|
作者：
RAVIKUMAR, VT
WYRZYKIEWICZ, TK
COLE, DL
机构：
[1] Isis Pharmaceuticals, Carlsbad, CA 92008
来源：
TETRAHEDRON | 1994年 / 50卷 / 31期
关键词：
D O I：
10.1016/S0040-4020(01)85503-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Diphenylmethylsilylethyl (DPSE) is a new protecting group for internucleotidic bonds in the synthesis of oligodeoxyribo nucleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild beta-fragmentation conditions using aqueous ammonium hydroxide.
引用
收藏
页码：9255 / 9266
页数：12
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