CALCIUM IONOPHORE POTENTIATES CHEMOTACTIC PEPTIDE AND PLATELET ACTIVATING FACTOR IN STIMULATING THROMBOXANE-B2 AND LEUKOTRIENE-B4 BIOSYNTHESIS IN HUMAN NEUTROPHILS

被引：1
|
作者：
TANIZAWA, H [1 ]
TAI, HH [1 ]
机构：
[1] UNIV KENTUCKY,COLL PHARM,DIV MED CHEM & PHARMACOGNOSY,LEXINGTON,KY 40536
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1990年 / 40卷 / 01期
关键词：
D O I：
10.1016/0952-3278(90)90115-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Formyl-Met-Leu-Phe (FMLP) and platelet activating factor (PAF) stimulated the synthesis of thromboxane B2 (TXB2) and leukotriene B4 (LTB4) to a small degree in human neutrophils. Calcium ionophore A-23187 enhanced synergistically both FMLP and PAF induced eicosanoid synthesis, whereas phorbol ester PMA attenuated PAF but not FMLP stimulated arachidonate metabolism. These results suggest that calcium mobilization may be a rate limiting step in FMLP and PAF induced synthesis of TXB2 and LTB4 and that protein kinase C activation may play a negative regulatory role in PAF stimulated eicosanoid synthesis. © 1990.
引用
收藏
页码：45 / 49
页数：5
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