CALCIUM IONOPHORE POTENTIATES CHEMOTACTIC PEPTIDE AND PLATELET ACTIVATING FACTOR IN STIMULATING THROMBOXANE-B2 AND LEUKOTRIENE-B4 BIOSYNTHESIS IN HUMAN NEUTROPHILS

被引：1

作者：

TANIZAWA, H ^{[1
]}

TAI, HH ^{[1
]}

机构：

[1] UNIV KENTUCKY,COLL PHARM,DIV MED CHEM & PHARMACOGNOSY,LEXINGTON,KY 40536

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1990年 / 40卷 / 01期

关键词：

D O I：

10.1016/0952-3278(90)90115-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Formyl-Met-Leu-Phe (FMLP) and platelet activating factor (PAF) stimulated the synthesis of thromboxane B2 (TXB2) and leukotriene B4 (LTB4) to a small degree in human neutrophils. Calcium ionophore A-23187 enhanced synergistically both FMLP and PAF induced eicosanoid synthesis, whereas phorbol ester PMA attenuated PAF but not FMLP stimulated arachidonate metabolism. These results suggest that calcium mobilization may be a rate limiting step in FMLP and PAF induced synthesis of TXB2 and LTB4 and that protein kinase C activation may play a negative regulatory role in PAF stimulated eicosanoid synthesis. © 1990.

引用

页码：45 / 49

页数：5

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