PROLONGED SHEDDING OF AMANTADINE-RESISTANT INFLUENZA-A VIRUSES BY IMMUNODEFICIENT PATIENTS - DETECTION BY POLYMERASE CHAIN-REACTION - RESTRICTION ANALYSIS

被引：127
|
作者：
KLIMOV, AI
ROCHA, E
HAYDEN, FG
SHULT, PA
ROUMILLAT, LF
COX, NJ
机构：
[1] CTR DIS CONTROL & PREVENT,INFLUENZA BRANCH,ATLANTA,GA 30333
[2] UNIV VIRGINIA,SCH MED,DEPT INTERNAL MED,CHARLOTTESVILLE,VA 22908
[3] UNIV VIRGINIA,SCH MED,DEPT PATHOL,CHARLOTTESVILLE,VA 22908
[4] UNIV WISCONSIN,WISCONSIN STATE LAB HYG,MADISON,WI 53706
来源：
JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 05期
关键词：
D O I：
10.1093/infdis/172.5.1352
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Consecutive A (H3N2) influenza virus isolates from 2 influenza virus-infected immunodeficient patients treated with amantadine were examined using a novel polymerase chain reaction (PCR)-restriction analysis for resistance to this antiviral compound. The data indicate that immunodeficient patients may shed resistant viruses for prolonged periods and with different drug resistance mutations present at different times. This PCR-restriction technique allows rapid detection of amantadine- or rimantadine-resistant strains.
引用
收藏
页码：1352 / 1355
页数：4
相关论文
共 50 条
  • [31] RAPID IDENTIFICATION OF MYCOBACTERIA TO THE SPECIES LEVEL BY POLYMERASE CHAIN-REACTION AND RESTRICTION ENZYME ANALYSIS
    TELENTI, A
    MARCHESI, F
    BALZ, M
    BALLY, F
    BOTTGER, EC
    BODMER, T
    JOURNAL OF CLINICAL MICROBIOLOGY, 1993, 31 (02) : 175 - 178
  • [32] DETECTION OF THE GLANZMANN THROMBASTHENIA MUTATIONS IN ARAB AND IRAQI-JEWISH PATIENTS BY POLYMERASE CHAIN-REACTION AND RESTRICTION ANALYSIS OF BLOOD OR URINE SAMPLES
    PERETZ, H
    SELIGSOHN, U
    ZWANG, E
    COLLER, BS
    NEWMAN, PJ
    THROMBOSIS AND HAEMOSTASIS, 1991, 66 (04) : 500 - 504
  • [33] RAPID DISTINCTION OF BREVIBACTERIUM SPECIES BY RESTRICTION ANALYSIS OF RDNA GENERATED BY POLYMERASE CHAIN-REACTION
    CARLOTTI, A
    FUNKE, G
    SYSTEMATIC AND APPLIED MICROBIOLOGY, 1994, 17 (03) : 380 - 386
  • [34] DETECTION OF SMALL ROUND STRUCTURED VIRUSES IN CLINICAL AND ENVIRONMENTAL-SAMPLES BY POLYMERASE CHAIN-REACTION
    WOLFAARDT, M
    MOE, CL
    GRABOW, WOK
    WATER SCIENCE AND TECHNOLOGY, 1995, 31 (5-6) : 375 - 382
  • [35] DETECTION OF SSTI RESTRICTION SITE POLYMORPHISM IN HUMAN APOC3 BY THE POLYMERASE CHAIN-REACTION
    HIXSON, JE
    VERNIER, DT
    POWERS, PK
    NUCLEIC ACIDS RESEARCH, 1991, 19 (01) : 196 - 196
  • [36] SIMULTANEOUS POLYMERASE CHAIN-REACTION DETECTION AND RESTRICTION TYPING FOR THE DIAGNOSIS OF HUMAN GENITAL PAPILLOMAVIRUS INFECTION
    PIZZIGHELLA, S
    PISONI, G
    BEVILACQUA, F
    VAONA, A
    PALU, G
    JOURNAL OF VIROLOGICAL METHODS, 1995, 55 (02) : 245 - 256
  • [37] A RAPID METHOD OF SAMPLE PREPARATION FOR DETECTION OF DNA VIRUSES IN HUMAN SERUM BY POLYMERASE CHAIN-REACTION
    FRICKHOFEN, N
    YOUNG, NS
    JOURNAL OF VIROLOGICAL METHODS, 1991, 35 (01) : 65 - 72
  • [38] DETECTION OF HEPATIC MICROMETASTASIS IN PANCREATIC ADENOCARCINOMA PATIENTS BY 2-STAGE POLYMERASE CHAIN-REACTION RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM ANALYSIS
    INOUE, S
    NAKAO, A
    KASAI, Y
    HARADA, A
    NONAMI, T
    TAKAGI, H
    JAPANESE JOURNAL OF CANCER RESEARCH, 1995, 86 (07): : 626 - 630
  • [39] POLYMERASE CHAIN-REACTION DETECTION OF CIRCULATING MELANOCYTES AS A PROGNOSTIC MARKER IN PATIENTS WITH MELANOMA
    BATTAYANI, Z
    GROB, JJ
    XERRI, L
    NOE, C
    ZAROUR, H
    HOUVAENEGHEL, G
    DELPERO, JR
    BIRMBAUM, D
    HASSOUN, J
    BONERANDI, JJ
    ARCHIVES OF DERMATOLOGY, 1995, 131 (04) : 443 - 447
  • [40] DETECTION OF BORRELIA BURGDORFERI IN PATIENTS WITH LYME-DISEASE BY THE POLYMERASE CHAIN-REACTION
    GUY, EC
    STANEK, G
    JOURNAL OF CLINICAL PATHOLOGY, 1991, 44 (07) : 610 - 611
12345