PROLONGED SHEDDING OF AMANTADINE-RESISTANT INFLUENZA-A VIRUSES BY IMMUNODEFICIENT PATIENTS - DETECTION BY POLYMERASE CHAIN-REACTION - RESTRICTION ANALYSIS

被引：127
|
作者：
KLIMOV, AI
ROCHA, E
HAYDEN, FG
SHULT, PA
ROUMILLAT, LF
COX, NJ
机构：
[1] CTR DIS CONTROL & PREVENT,INFLUENZA BRANCH,ATLANTA,GA 30333
[2] UNIV VIRGINIA,SCH MED,DEPT INTERNAL MED,CHARLOTTESVILLE,VA 22908
[3] UNIV VIRGINIA,SCH MED,DEPT PATHOL,CHARLOTTESVILLE,VA 22908
[4] UNIV WISCONSIN,WISCONSIN STATE LAB HYG,MADISON,WI 53706
来源：
JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 05期
关键词：
D O I：
10.1093/infdis/172.5.1352
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Consecutive A (H3N2) influenza virus isolates from 2 influenza virus-infected immunodeficient patients treated with amantadine were examined using a novel polymerase chain reaction (PCR)-restriction analysis for resistance to this antiviral compound. The data indicate that immunodeficient patients may shed resistant viruses for prolonged periods and with different drug resistance mutations present at different times. This PCR-restriction technique allows rapid detection of amantadine- or rimantadine-resistant strains.
引用
收藏
页码：1352 / 1355
页数：4
相关论文
共 50 条
  • [21] RAPID DETECTION OF WATERBORNE VIRUSES USING THE POLYMERASE CHAIN-REACTION AND A GENE PROBE
    JOTHIKUMAR, N
    KHANNA, P
    KAMATCHIAMMAL, S
    MURUGAN, RP
    INTERVIROLOGY, 1992, 34 (04) : 184 - 191
  • [22] ANALYSIS AND PURIFICATION OF DNA RESTRICTION FRAGMENTS AND POLYMERASE CHAIN-REACTION PRODUCTS BY HPLC
    WHEAT, TE
    WARREN, WJ
    FASEB JOURNAL, 1991, 5 (04): : A884 - A884
  • [23] ANALYSIS OF DNA RESTRICTION FRAGMENTS AND POLYMERASE CHAIN-REACTION PRODUCTS BY CAPILLARY ELECTROPHORESIS
    WILLIAMS, PE
    MARINO, MA
    DELRIO, SA
    TURNI, LA
    DEVANEY, JM
    JOURNAL OF CHROMATOGRAPHY A, 1994, 680 (02) : 525 - 540
  • [24] RAPID DETECTION OF INFLUENZA-VIRUS H1 BY THE POLYMERASE CHAIN-REACTION
    BRESSOUD, A
    WHITCOMB, J
    POURZAND, C
    HALLER, O
    CERUTTI, P
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 167 (02) : 425 - 430
  • [25] DETECTION OF INFLUENZA-B VIRUS IN THROAT SWABS USING THE POLYMERASE CHAIN-REACTION
    YAMADA, A
    IMANISHI, J
    ACTA VIROLOGICA, 1992, 36 (03) : 320 - 325
  • [26] DETECTION AND DIFFERENTIATION OF FUNGI IN CLINICAL SPECIMENS USING POLYMERASE CHAIN-REACTION (PCR) AMPLIFICATION AND RESTRICTION ENZYME ANALYSIS
    HOPFER, RL
    WALDEN, P
    SETTERQUIST, S
    HIGHSMITH, WE
    JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY, 1993, 31 (01): : 65 - 75
  • [27] DETECTION OF TOXOPLASMA-GONDII IN AIDS PATIENTS BY THE POLYMERASE CHAIN-REACTION
    CRISTINA, N
    PELLOUX, H
    GOULHOT, C
    BRION, JP
    LECLERCQ, P
    AMBROISETHOMAS, P
    INFECTION, 1993, 21 (03) : 150 - 153
  • [28] POLYMERASE CHAIN-REACTION FOR THE DETECTION OF HELICOBACTER-PYLORI IN PATIENTS AND ENDOSCOPES
    KUIPERS, EJ
    ROOSENDAAL, R
    UYTERLINDE, AM
    PENA, AS
    DEGRAAFF, H
    VANKAMP, G
    VANDENBRULE, AJC
    MEUWISSEN, SGM
    GASTROENTEROLOGY, 1993, 104 (04) : A124 - A124
  • [29] DETECTION OF HUMAN CYTOMEGALOVIRUS BY THE POLYMERASE CHAIN-REACTION IN IMMUNOSUPPRESSED AND IMMUNOCOMPROMISED PATIENTS
    ERGAZAKI, M
    XINARIANOS, G
    KOFFA, M
    LILOGLOU, T
    SPANDIDOS, DA
    ONCOLOGY REPORTS, 1994, 1 (04) : 805 - 808
  • [30] TYPING OF CHLAMYDIA SPP BY RESTRICTION ENDONUCLEASE ANALYSIS COMBINED WITH POLYMERASE CHAIN-REACTION (PCR)
    KOMATSU, M
    JAPANESE JOURNAL OF VETERINARY RESEARCH, 1992, 40 (01) : 39 - 39
12345