13-CIS-RETINOIC ACID PLUS INTERFERON-ALPHA - A PHASE-II CLINICAL-STUDY IN SQUAMOUS-CELL CARCINOMA OF THE LUNG AND THE HEAD AND NECK

被引：0
|
作者：
ROTH, AD [1 ]
ABELE, R [1 ]
ALBERTO, P [1 ]
机构：
[1] GENEVA UNIV HOSP,DIV ONCOHEMATOL,CH-1211 GENEVA 14,SWITZERLAND
来源：
ONCOLOGY | 1994年 / 51卷 / 01期
关键词：
RETINOID; 13-CIS-RETINOIC ACID; INTERFERON-ALPHA; SQUAMOUS CELL CARCINOMA; RETINOID TOXICITY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Retinoids and interferon-alpha (IFN-alpha) have been shown to have a synergetic antiproliferative and differentiative effect on many cell lines, and in combination they have already been tested with some success in the treatment of some tumors. We investigated the tolerance and efficacy of high dose 13-cis-retinoic acid (2 mg/kg/day) and IFN-alpha in the treatment of advanced squamous cell carcinoma of the lung and of the head and neck. No partial or complete response was observed in the 10 patients treated. The toxicity was unusual and mild to moderate considering the dose of retinoid given. This observation leads us to suspect that IFN-alpha may alleviate some of the side effects of the retinoid, and is of interest in the design of future clinical trials.
引用
收藏
页码：84 / 86
页数：3
相关论文
共 50 条
  • [41] A BROAD PHASE-II TRIAL OF 13-CIS-RETINOIC ACID IN ADVANCED CANCER
    MEYSKENS, FL
    GILMARTIN, E
    CHASE, E
    ALBERTS, D
    SURWIT, E
    JONES, SE
    SALMON, SE
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1981, 22 (MAR): : 370 - 370
  • [42] A PHASE-II STUDY OF PIRARUBICIN IN PATIENTS WITH ADVANCED RECURRENT HEAD AND NECK SQUAMOUS-CELL CARCINOMA
    DEMULDER, PHM
    CAPPELAERE, P
    COGNETTI, F
    VERWEIJ, J
    SCHORNAGEL, JH
    VERMORKEN, JB
    KIRKPATRICK, A
    LEFEBVRE, JL
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1994, 33 (05) : 438 - 440
  • [43] PHASE-II CLINICAL-STUDY OF YOSHI-864 IN SQUAMOUS-CELL CARCINOMA OF THE UTERINE CERVIX
    SLAVIK, M
    MUSS, H
    BLESSING, JA
    CANCER TREATMENT REPORTS, 1983, 67 (02): : 195 - 196
  • [44] Induction of cell cycle arrest and apoptosis by a combined treatment with 13-cis-retinoic acid, interferon-α2a, and α-tocopherol in squamous cell carcinoma of the head and neck
    Zhang, Xin
    Chen, Zhuo
    Khuri, Fadlo R.
    Shin, Dong M.
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2007, 29 (04): : 351 - 361
  • [45] PHASE-II TRIAL OF MITOGUAZONE IN PATIENTS WITH ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    PERRY, DJ
    CRAIN, SM
    WELTZ, MD
    WILSON, JP
    DAVIS, RK
    WOOLLEY, PV
    FORASTIERE, AA
    TAYLOR, HG
    WEISS, RB
    CANCER TREATMENT REPORTS, 1983, 67 (01): : 91 - 92
  • [46] PHASE-II TRIAL OF HOMOHARRINGTONINE (HHT) IN SQUAMOUS-CELL CARCINOMA OF THE HEAD NECK (SCCHN)
    DIMERY, IW
    LEGHA, S
    GOEPFERT, H
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1984, 25 (MAR): : 181 - 181
  • [47] Phase II trial of interferon-alpha in locally recurrent or metastatic squamous cell carcinoma of the head and neck: Immunological and clinical correlates
    Vlock, DR
    Andersen, J
    Kalish, LA
    Johnson, JT
    Kirkwood, JM
    Whiteside, T
    Herberman, RB
    Adams, GS
    Oken, MM
    Haselow, RE
    JOURNAL OF IMMUNOTHERAPY, 1996, 19 (06): : 433 - 442
  • [48] PHASE-II TRIAL OF ICRF-187 IN SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    WHEELER, RH
    BRICKER, LJ
    NATALE, RB
    BAKER, SR
    CANCER TREATMENT REPORTS, 1984, 68 (02): : 427 - 428
  • [49] A PHASE-II TRIAL OF ACLACINOMYCIN-A IN ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    ECKENRODE, JL
    WHEELER, RH
    FORASTIERE, AA
    INVESTIGATIONAL NEW DRUGS, 1985, 3 (04) : 389 - 392
  • [50] A PHASE-II STUDY OF MITOXANTRONE IN ADVANCED SQUAMOUS-CELL CANCER OF THE HEAD AND NECK
    WHEELER, H
    WOODS, RL
    PAGE, J
    LEVI, J
    INVESTIGATIONAL NEW DRUGS, 1990, 8 (01) : 109 - 111
12345