13-CIS-RETINOIC ACID PLUS INTERFERON-ALPHA - A PHASE-II CLINICAL-STUDY IN SQUAMOUS-CELL CARCINOMA OF THE LUNG AND THE HEAD AND NECK

被引：0
|
作者：
ROTH, AD [1 ]
ABELE, R [1 ]
ALBERTO, P [1 ]
机构：
[1] GENEVA UNIV HOSP,DIV ONCOHEMATOL,CH-1211 GENEVA 14,SWITZERLAND
来源：
ONCOLOGY | 1994年 / 51卷 / 01期
关键词：
RETINOID; 13-CIS-RETINOIC ACID; INTERFERON-ALPHA; SQUAMOUS CELL CARCINOMA; RETINOID TOXICITY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Retinoids and interferon-alpha (IFN-alpha) have been shown to have a synergetic antiproliferative and differentiative effect on many cell lines, and in combination they have already been tested with some success in the treatment of some tumors. We investigated the tolerance and efficacy of high dose 13-cis-retinoic acid (2 mg/kg/day) and IFN-alpha in the treatment of advanced squamous cell carcinoma of the lung and of the head and neck. No partial or complete response was observed in the 10 patients treated. The toxicity was unusual and mild to moderate considering the dose of retinoid given. This observation leads us to suspect that IFN-alpha may alleviate some of the side effects of the retinoid, and is of interest in the design of future clinical trials.
引用
收藏
页码：84 / 86
页数：3
相关论文
共 50 条
  • [21] Combined interferon-alfa, 13-cis-retinoic acid, and alpha-tocopherol in locally advanced head and neck squamous cell carcinoma:: Novel bioadjuvant phase II trial
    Shin, DM
    Khuri, FR
    Murphy, B
    Garden, AS
    Clayman, G
    Francisco, M
    Liu, D
    Glisson, BS
    Ginsberg, L
    Papadimitrakopoulou, V
    Myers, J
    Morrison, W
    Gillenwater, A
    Ang, KK
    Lippman, SM
    Goepfert, H
    Hong, WK
    JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (12) : 3010 - 3017
  • [22] PHASE-II STUDY OF DOXIFLURIDINE IN ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    ABELE, R
    KAPLAN, E
    GROSSENBACHER, R
    SCHMID, HJ
    CAVALLI, F
    EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1984, 20 (03): : 333 - 336
  • [23] 13-CIS-RETINOIC ACID PLUS INTERFERON-ALPHA IN SOLID TUMORS - KEEPING THE CART BEHIND THE HORSE
    LIPPMAN, SM
    HONG, WK
    ANNALS OF ONCOLOGY, 1994, 5 (05) : 391 - 393
  • [24] Pilot phase II trial of 13-cis-retinoic acid and interferon-alpha combination therapy for advanced pancreatic adenocarcinoma
    Moore, DF
    Pazdur, R
    Sugarman, S
    Jones, D
    Lippman, SM
    Bready, B
    Abbruzzese, JL
    AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1995, 18 (06): : 525 - 527
  • [25] 13-cis-retinoic acid and interferon-alpha 2a as palliative therapy of pretreated, recurrent squamous cell carcinoma of the uterine cervix and vulva
    Romisch, M
    Meier, W
    Kimmig, R
    Hepp, H
    GEBURTSHILFE UND FRAUENHEILKUNDE, 1996, 56 (10) : 520 - 524
  • [26] 13-cis-retinoic acid and alpha-interferon in advanced squamous cell cancer of the oesophagus
    Kok, TC
    vanderGaast, A
    Splinter, TAW
    EUROPEAN JOURNAL OF CANCER, 1997, 33 (01) : 165 - 166
  • [27] A PHASE-II STUDY OF ADRIAMYCIN IN PREVIOUSLY UNTREATED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    COBLEIGH, MA
    HILL, JH
    GALLAGHER, PA
    KUKLA, LJ
    LAD, TE
    SHEVRIN, DH
    APPLEBAUM, EL
    MCGUIRE, WP
    CANCER, 1985, 56 (11) : 2573 - 2575
  • [28] PHASE-II STUDY OF ETOPOSIDE IN PREVIOUSLY UNTREATED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    COBLEIGH, MA
    HILL, JH
    LAD, TE
    SHEVRIN, DE
    APPLEBAUM, EL
    CANCER TREATMENT REPORTS, 1987, 71 (03): : 321 - 322
  • [29] A PHASE-II STUDY OF PIRITREXIM IN PATIENTS WITH ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    DEGARDIN, M
    DOMENGE, C
    CAPPELAERE, P
    LUBOINSKI, B
    NAVARRETE, MS
    SCOTT, JE
    LEFEBVRE, JL
    EUROPEAN JOURNAL OF CANCER, 1994, 30A (07) : 1044 - 1045
  • [30] VINORELBINE IN PRETREATED ADVANCED HEAD AND NECK SQUAMOUS-CELL CARCINOMA - A PHASE-II STUDY
    TESTOLIN, A
    RECHER, G
    CRISTOFERI, V
    GASPARINI, G
    INVESTIGATIONAL NEW DRUGS, 1994, 12 (03) : 231 - 234
12345