CLONING AND EXPRESSION OF THE CDNA-ENCODING RABBIT LIVER CARBONYL REDUCTASE

被引：30
|
作者：
GONZALEZ, B
SAPRA, A
RIVERA, H
KAPLAN, WD
YAM, B
FORREST, GL
机构：
[1] BECKMAN RES INST CITY HOPE,DIV BIOL,DUARTE,CA 91010
[2] STANFORD UNIV,STANFORD,CA 94305
[3] UNIV CALIF SANTA CRUZ,SANTA CRUZ,CA 95060
来源：
GENE | 1995年 / 154卷 / 02期
关键词：
CDNA; DAUNORUBICIN REDUCTASE; QUINONE REDUCTASE; DRUG METABOLISM;
D O I：
10.1016/0378-1119(94)00843-H
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Two cDNA sequences encoding rabbit carbonyl reductase (CBR) were cloned from a lambda gt10 rabbit liver cDNA library, The rabbit cDNAs coded for a protein with 84% identity to human CBR. Transient expression of the two rabbit cDNA sequences in COS7 cells increased both quinone reductase and aldo-keto reductase activities. These data demonstrate that CBR cDNAs from rabbit and human tissues code for similar proteins.
引用
收藏
页码：297 / 298
页数：2
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