CLONING AND EXPRESSION OF CDNA-ENCODING HUMAN BETACELLULIN, A NEW MEMBER OF THE EGF FAMILY

被引：114
|
作者：
SASADA, R [1 ]
ONO, Y [1 ]
TANIYAMA, Y [1 ]
SHING, Y [1 ]
FOLKMAN, J [1 ]
IGARASHI, K [1 ]
机构：
[1] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT SURG,BOSTON,MA 02115
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 190卷 / 03期
关键词：
D O I：
10.1006/bbrc.1993.1173
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Betacellulin (BTC) is a novel growth factor purified from the conditioned media of mouse pancreatic beta tumor cells and has been found to be a new member of the epidermal growth factor (EGF) family. The cDNA encoding human BTC has been cloned from a cDNA library prepared from human breast adenocarcinoma cell line MCF-7. The nucleotide sequence encodes a polypeptide which consists of 178 amino acid residues including a putative signal sequence, indicating that the structural organization of human BTC is similar to that of mouse BTC. The amino acid sequence of the human BTC precursor protein exhibits 79% similarity with that of the mouse precursor protein. The BTC gene was found to be expressed in several mouse tissues including kidney and liver as well as in a mouse beta tumor cell line and MCF-7 cells, suggesting that BTC might play a physiological role in normal tissues. © 1993 Academic Press, Inc.
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收藏
页码：1173 / 1179
页数：7
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