PHARMACOKINETICS OF REC-HIRUDIN IN HEALTHY-VOLUNTEERS AFTER INTRAVENOUS ADMINISTRATION

被引：15
|
作者：
CARDOT, JMA
LEFEVRE, GY
GODBILLON, JA
机构：
[1] Laboratoires Ciba-Geigy, Centre de Recherche Biopharmaceutique, Rueil-Malmaison Cedex, F92506
来源：
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1994年 / 22卷 / 02期
关键词：
REC-HIRUDIN; PHARMACOKINETICS; ELISA; INTRAVENOUS ADMINISTRATION;
D O I：
10.1007/BF02353540
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The pharmacokinetics of recombinant hirudin (rec-hirudin, Ciba-Geigy, CGP 39 393) in healthy volunteers after iv administration was investigated on the basis of the data from Jive different studies. A total of 77 plasma profiles following a single iv bolus dose of either 0.1, 0.3, 0.5, or 1 mg/kg of rec-hirudin was used for the evualation. Plasma concentrations and especially AUC were proportional to the dose. Kinetics of rec-hirudin after a bolus iv injection were best described by a three-compartment open model. Mean apparent terminal half-life was 2.8 hr and the total clearance 0.138 L/hr per kg.
引用
收藏
页码：147 / 156
页数：10
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