PHARMACOKINETICS OF REC-HIRUDIN IN HEALTHY-VOLUNTEERS AFTER INTRAVENOUS ADMINISTRATION

被引：15

作者：

CARDOT, JMA

LEFEVRE, GY

GODBILLON, JA

机构：

[1] Laboratoires Ciba-Geigy, Centre de Recherche Biopharmaceutique, Rueil-Malmaison Cedex, F92506

来源：

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1994年 / 22卷 / 02期

关键词：

REC-HIRUDIN; PHARMACOKINETICS; ELISA; INTRAVENOUS ADMINISTRATION;

D O I：

10.1007/BF02353540

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacokinetics of recombinant hirudin (rec-hirudin, Ciba-Geigy, CGP 39 393) in healthy volunteers after iv administration was investigated on the basis of the data from Jive different studies. A total of 77 plasma profiles following a single iv bolus dose of either 0.1, 0.3, 0.5, or 1 mg/kg of rec-hirudin was used for the evualation. Plasma concentrations and especially AUC were proportional to the dose. Kinetics of rec-hirudin after a bolus iv injection were best described by a three-compartment open model. Mean apparent terminal half-life was 2.8 hr and the total clearance 0.138 L/hr per kg.

引用

页码：147 / 156

页数：10

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