Serum cytokine/chemokine profile and clinical/paraclinical data in COVID-19 deceased and recovered patients

被引:0
|
作者
Aghcheli, Bahman [1 ]
Behboudi, Emad [1 ]
Tabarraei, Alijan [1 ]
Nikoo, Hadi Razavi [1 ]
Rajabi, Abdolhalim [2 ]
Moradi, Abdolvahab [1 ]
Nakstad, Britt [3 ,4 ,7 ]
Tahamtan, Alireza [1 ,5 ,6 ]
机构
[1] Golestan Univ Med Sci, Fac Med, Dept Microbiol, Gorgan, Iran
[2] Golestan Univ Med Sci, Fac Hlth, Environm Hlth Res Ctr, Dept Biostat & Epidemiol, Gorgan, Iran
[3] Univ Oslo, Div Paediat & Adolescent Med, Oslo, Norway
[4] Univ Botswana, Dept Paediat & Adolescent Hlth, Gaborone, Botswana
[5] Golestan Univ Med Sci, Infect Dis Res Ctr, Gorgan, Iran
[6] Golestan Univ Med Sci, POB 4934174515, Gorgan, Iran
[7] Univ Oslo, Inst Clin Med Head Global Paediat Signatory Theme, Fac Med, Ctr Global Hlth,Div Paediat Adolescent Med, POB 4956 Nydalen OUS, N-0424 Oslo, Norway
关键词
coronavirus disease 2019; severe acute respiratory syndrome coronavirus 2; cytokine; chemokine profile; clinical; paraclinical data;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objectives: The induction of an intense immune response and cytokine storm is proposed to be central in the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study evaluated serum cytokine/chemokine profiles, and clinical and paraclinical data of COVID-19 deceased and recovered patients in Iran. Methods: The severity of disease, clinical data, and routine laboratory and inflammatory cytokine/chemokine responses were retrospectively explored in 60 in-hospital patients in northern Iran. Characteristics of those who deceased (n = 30) were compared to recovered (n = 30), and associations with serum levels of potential disease regulating pro- and anti-inflammatory mediators were studied. Results: The serum levels of IFN-gamma, IL-1 beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, IP-10, MIP1-alpha, MCP1, RANTES, and TNF-alpha were upregulated in all COVID-19 patients when compared to healthy and gender-matched individuals (n = 30). Although with no significant difference between deceased and recovered cases, the serum levels of all cytokines/chemokines tended to be higher in the severely diseased non-surviving patients. Association analyses revealed that all cytokine/chemokine levels (except IL-10) significantly affect the disease outcome. Conclusion: This study provides more evidence for the association of cytokine/chemokine levels with the clinical course and outcome of COVID-19. More studies are needed to consider this measurement as an indicator of disease stage and strategy for treatment.
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页数:16
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