Serum cytokine/chemokine profile and clinical/paraclinical data in COVID-19 deceased and recovered patients

被引:0
|
作者
Aghcheli, Bahman [1 ]
Behboudi, Emad [1 ]
Tabarraei, Alijan [1 ]
Nikoo, Hadi Razavi [1 ]
Rajabi, Abdolhalim [2 ]
Moradi, Abdolvahab [1 ]
Nakstad, Britt [3 ,4 ,7 ]
Tahamtan, Alireza [1 ,5 ,6 ]
机构
[1] Golestan Univ Med Sci, Fac Med, Dept Microbiol, Gorgan, Iran
[2] Golestan Univ Med Sci, Fac Hlth, Environm Hlth Res Ctr, Dept Biostat & Epidemiol, Gorgan, Iran
[3] Univ Oslo, Div Paediat & Adolescent Med, Oslo, Norway
[4] Univ Botswana, Dept Paediat & Adolescent Hlth, Gaborone, Botswana
[5] Golestan Univ Med Sci, Infect Dis Res Ctr, Gorgan, Iran
[6] Golestan Univ Med Sci, POB 4934174515, Gorgan, Iran
[7] Univ Oslo, Inst Clin Med Head Global Paediat Signatory Theme, Fac Med, Ctr Global Hlth,Div Paediat Adolescent Med, POB 4956 Nydalen OUS, N-0424 Oslo, Norway
关键词
coronavirus disease 2019; severe acute respiratory syndrome coronavirus 2; cytokine; chemokine profile; clinical; paraclinical data;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objectives: The induction of an intense immune response and cytokine storm is proposed to be central in the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study evaluated serum cytokine/chemokine profiles, and clinical and paraclinical data of COVID-19 deceased and recovered patients in Iran. Methods: The severity of disease, clinical data, and routine laboratory and inflammatory cytokine/chemokine responses were retrospectively explored in 60 in-hospital patients in northern Iran. Characteristics of those who deceased (n = 30) were compared to recovered (n = 30), and associations with serum levels of potential disease regulating pro- and anti-inflammatory mediators were studied. Results: The serum levels of IFN-gamma, IL-1 beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, IP-10, MIP1-alpha, MCP1, RANTES, and TNF-alpha were upregulated in all COVID-19 patients when compared to healthy and gender-matched individuals (n = 30). Although with no significant difference between deceased and recovered cases, the serum levels of all cytokines/chemokines tended to be higher in the severely diseased non-surviving patients. Association analyses revealed that all cytokine/chemokine levels (except IL-10) significantly affect the disease outcome. Conclusion: This study provides more evidence for the association of cytokine/chemokine levels with the clinical course and outcome of COVID-19. More studies are needed to consider this measurement as an indicator of disease stage and strategy for treatment.
引用
收藏
页数:16
相关论文
共 50 条
  • [21] Infectivity of deceased COVID-19 patients
    Plenzig, Stefanie
    Bojkova, D.
    Held, H.
    Berger, A.
    Holz, F.
    Cinatl, J.
    Gradhand, E.
    Kettner, M.
    Pfeiffer, A.
    Verhoff, M. A.
    Ciesek, S.
    INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2021, 135 (05) : 2055 - 2060
  • [22] Cytokine and chemokine signature of COVID-19 and predictive markers
    Ranjbar, Maral
    Cusack, Ruth
    Whetstone, Christiane
    Nawaz, Shiraz
    Khoury, Christopher
    Wattie, Jennifer
    Wiltshire, Lesley
    Le Roux, Jennifer
    Cheng, Eric
    Srinathan, Thivya
    Ho, Terence
    Sehmi, Roma
    Duong, Mylinh
    Gauvreau, Gail
    EUROPEAN RESPIRATORY JOURNAL, 2023, 62
  • [23] Cytokine and chemokine profiles in the sera of COVID-19 patients with different stages of severity
    Bourhis, Maryam
    Idir, Abderrazak
    Machraoui, Safa
    Hachimi, Abdelhamid
    Elouardi, Youssef
    Jamil, Oumayma
    Khallouki, Mohammed
    Zahlane, Kawtar
    Guennouni, Morad
    Hazime, Raja
    Essaadouni, Lamiaa
    Lourhlam, Bouchra
    Ennaji, Moulay Mustapha
    Mouse, Hassan Ait
    Admou, Brahim
    Zyad, Abdelmajid
    CYTOKINE, 2024, 180
  • [24] Clinical and Cytokine Profile of Children With COVID-19: A Report From Turkey
    Dalkiran, Tahir
    Kara, Emine M.
    Unsal, Velid
    Yurttutan, Sadik
    Ipek, Sevcan
    Dagoglu, Besra
    Kandur, Yasal
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (04)
  • [25] Dysosmia in Recovered COVID-19 Patients
    Abdel-Aziz, Mosaad
    Azab, Noha
    JOURNAL OF CRANIOFACIAL SURGERY, 2023, 34 (03) : 843 - 844
  • [26] Mucormycosis in COVID-19 recovered patients
    Kumar, Anoop
    JOURNAL OF MEDICAL VIROLOGY, 2022, 94 (04) : 1272 - 1273
  • [27] Clinical and demographic characteristics of deceased patients due to COVID-19 in Bihar
    Rai, Deependra Kumar
    LUNG INDIA, 2021, 38 (07) : S125 - S127
  • [28] Epidemiological, clinical, paraclinical, evolutionary and therapeutic aspects of hypertensive patients infected with COVID-19
    Ngaide, A. A.
    Gaye, N. D.
    Wade, I.
    Kane, A.
    EUROPEAN JOURNAL OF HEART FAILURE, 2024, 26 : 164 - 165
  • [29] Effect of antiviral and immunomodulatory treatment on a cytokine profile in patients with COVID-19
    Martonik, Diana
    Parfieniuk-Kowerda, Anna
    Starosz, Aleksandra
    Grubczak, Kamil
    Moniuszko, Marcin
    Flisiak, Robert
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [30] Impact of Viral Decontamination Method on Cytokine Profile of COVID-19 Patients
    Magri, Davide
    Navarro, Anna
    Bergami, Federica
    Percivalle, Elena
    Ferrari, Alessandro
    Lettieri, Teresa
    Calzolai, Luigi
    Piralla, Antonio
    Baldanti, Fausto
    Gioria, Sabrina
    BIOMEDICINES, 2021, 9 (10)